Table 3 Summary of significant... | American Society of Hematology

Table 3

Summary of significant associations (P < .05) between aGVHD and candidate SNPs

Gene	Phenotype	Genome	Donor type	SNP	Alleles	MAF*	Model	HR	Unadjusted CI	P	HR	Adjusted CI†	P
IL2	III-IV	DNR	URD	rs2069762	C/A	0.34	Allelic	1.16	(0.96-1.40)	.1293	1.15	(0.94-1.40)	.1811
							Recessive	1.04	(0.70-1.55)	.8466	0.98	(0.64-1.50)	.9310
							Dominant	1.32	(1.00-1.74)	.0487	1.33	(0.99-1.78)	.0557
IL6	IIb-IV	DNR	URD	rs1800795	C/G	0.39	Allelic	1.21	(1.07-1.36)	.0028	1.19	(1.04-1.36)	.0106
							Recessive	1.48	(1.19-1.84)	.0004	1.44	(1.15-1.81)	.0013
							Dominant	1.17	(0.97-1.40)	.0966	1.13	(0.93-1.38)	.2231
IL6	IIb-IV	PT	MRD	rs1800795	C/G	0.34	Allelic	0.87	(0.73-1.04)	.1362	0.8	(0.66-0.97)	.0240
							Recessive	0.84	(0.57-1.25)	.3983	0.81	(0.54-1.20)	.2923
							Dominant	0.84	(0.66-1.06)	.1444	0.74	(0.57-0.95)	.0195
IL6	III-IV	DNR	MRD	rs1800795	C/G	0.36	Allelic	1.26	(0.98-1.63)	.0719	1.27	(0.97-1.67)	.0864
							Recessive	1.09	(0.65-1.82)	.7360	1.06	(0.63-1.79)	.8177
							Dominant	1.54	(1.05-2.26)	.0257	1.59	(1.05-2.41)	.0279
IL10	III-IV	PT	MRD	rs1800872	T/G	0.24	Allelic	0.72	(0.52-1.00)	.0481	0.73	(0.52-1.04)	.0796
							Recessive	0	(0.00,Inf)	.9817	0	(0.00,Inf)	.9815
							Dominant	0.82	(0.56-1.19)	.2933	0.85	(0.58-1.25)	.4035
IL10	III-IV	PT	MRD	rs1800871	A/G	0.24	Allelic	0.72	(0.52-1.00)	.0481	0.73	(0.52-1.04)	.0796
							Recessive	0	(0.00,Inf)	.9817	0	(0.00,Inf)	.9815
							Dominant	0.82	(0.56-1.19)	.2933	0.85	(0.58-1.25)	.4035
CTLA4	III-IV	PT	URD	rs3087243	A/G	0.45	Allelic	1.17	(0.97-1.42)	.1042	1.23	(1.01-1.50)	.0374
							Recessive	1	(0.72-1.41)	.9782	1.05	(0.74-1.49)	.7870
							Dominant	1.5	(1.09-2.07)	.0138	1.65	(1.18-2.30)	.0035
HPSE	IIb-IV	DNR	URD	rs4364254	C/T	0.29	Allelic	1.07	(0.93-1.22)	.3377	1.11	(0.97-1.27)	.1453
							Recessive	0.91	(0.66-1.26)	.5736	0.95	(0.68-1.33)	.7767
							Dominant	1.15	(0.97-1.37)	.1158	1.21	(1.01-1.45)	.0415
MTHFR	III-IV	PT	MRD	rs1801131	G/T	0.29	Allelic	0.88	(0.67-1.17)	.3870	0.84	(0.63-1.11)	.2157
							Recessive	1.29	(0.76-2.19)	.3408	1.22	(0.71-2.08)	.4679
							Dominant	0.71	(0.49-1.04)	.0764	0.66	(0.45-0.96)	.0309

Gene	Phenotype	Genome	Donor type	SNP	Alleles	MAF*	Model	HR	Unadjusted CI	P	HR	Adjusted CI†	P
IL2	III-IV	DNR	URD	rs2069762	C/A	0.34	Allelic	1.16	(0.96-1.40)	.1293	1.15	(0.94-1.40)	.1811
							Recessive	1.04	(0.70-1.55)	.8466	0.98	(0.64-1.50)	.9310
							Dominant	1.32	(1.00-1.74)	.0487	1.33	(0.99-1.78)	.0557
IL6	IIb-IV	DNR	URD	rs1800795	C/G	0.39	Allelic	1.21	(1.07-1.36)	.0028	1.19	(1.04-1.36)	.0106
							Recessive	1.48	(1.19-1.84)	.0004	1.44	(1.15-1.81)	.0013
							Dominant	1.17	(0.97-1.40)	.0966	1.13	(0.93-1.38)	.2231
IL6	IIb-IV	PT	MRD	rs1800795	C/G	0.34	Allelic	0.87	(0.73-1.04)	.1362	0.8	(0.66-0.97)	.0240
							Recessive	0.84	(0.57-1.25)	.3983	0.81	(0.54-1.20)	.2923
							Dominant	0.84	(0.66-1.06)	.1444	0.74	(0.57-0.95)	.0195
IL6	III-IV	DNR	MRD	rs1800795	C/G	0.36	Allelic	1.26	(0.98-1.63)	.0719	1.27	(0.97-1.67)	.0864
							Recessive	1.09	(0.65-1.82)	.7360	1.06	(0.63-1.79)	.8177
							Dominant	1.54	(1.05-2.26)	.0257	1.59	(1.05-2.41)	.0279
IL10	III-IV	PT	MRD	rs1800872	T/G	0.24	Allelic	0.72	(0.52-1.00)	.0481	0.73	(0.52-1.04)	.0796
							Recessive	0	(0.00,Inf)	.9817	0	(0.00,Inf)	.9815
							Dominant	0.82	(0.56-1.19)	.2933	0.85	(0.58-1.25)	.4035
IL10	III-IV	PT	MRD	rs1800871	A/G	0.24	Allelic	0.72	(0.52-1.00)	.0481	0.73	(0.52-1.04)	.0796
							Recessive	0	(0.00,Inf)	.9817	0	(0.00,Inf)	.9815
							Dominant	0.82	(0.56-1.19)	.2933	0.85	(0.58-1.25)	.4035
CTLA4	III-IV	PT	URD	rs3087243	A/G	0.45	Allelic	1.17	(0.97-1.42)	.1042	1.23	(1.01-1.50)	.0374
							Recessive	1	(0.72-1.41)	.9782	1.05	(0.74-1.49)	.7870
							Dominant	1.5	(1.09-2.07)	.0138	1.65	(1.18-2.30)	.0035
HPSE	IIb-IV	DNR	URD	rs4364254	C/T	0.29	Allelic	1.07	(0.93-1.22)	.3377	1.11	(0.97-1.27)	.1453
							Recessive	0.91	(0.66-1.26)	.5736	0.95	(0.68-1.33)	.7767
							Dominant	1.15	(0.97-1.37)	.1158	1.21	(1.01-1.45)	.0415
MTHFR	III-IV	PT	MRD	rs1801131	G/T	0.29	Allelic	0.88	(0.67-1.17)	.3870	0.84	(0.63-1.11)	.2157
							Recessive	1.29	(0.76-2.19)	.3408	1.22	(0.71-2.08)	.4679
							Dominant	0.71	(0.49-1.04)	.0764	0.66	(0.45-0.96)	.0309

Allo indicates allogeneic; CI, confidence interval; DNR, donor, HR, hazard ratio MAF, minor allele frequency; MRD, matched related donor; NR, not reported; PT, patient; SNP, single-nucleotide polymorphism; and URD, unrelated donor.

The first allele is designated as the minor allele, and the second allele is designated as the major allele.

†

Models adjusted for total body irradiation (yes vs no), sex mismatch, and 4 principal components for population stratification. Matched related donor analyses are also adjusted for HLA match.

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