Table 1

The PKC family of enzymes, their expression in mouse neutrophils, their activators, and their inhibitors

SubfamilyIsoformsDirect activatorsAgonists
cPKC α* βI† βII* γ† DAG + Ca2+ fMLP,37  PMA (β), Fc (β)47  
nPKC δI-III* ϵ‡ η‡ θI-III‡ DAG fMLP (δ)37,44  
aPKC ζ* ι/λ†  fMLP (ζ)38  
SubfamilyIsoformsDirect activatorsAgonists
cPKC α* βI† βII* γ† DAG + Ca2+ fMLP,37  PMA (β), Fc (β)47  
nPKC δI-III* ϵ‡ η‡ θI-III‡ DAG fMLP (δ)37,44  
aPKC ζ* ι/λ†  fMLP (ζ)38  
InhibitorIC50 for PKC isoforms, μM
α*βI†βII*γ†δ*ϵ‡ζ*η‡μ†ι/λ†
BIM-I48-50  0.008 0.017 0.016 0.020 0.21 0.132 5.8 § 2 § 
Gö 697648,49,51  0.0023 0.006 0.002-0.0079 0.002-0.006 — — — § 0.02 § 
Gö 698348  0.007 0.007 0.007 0.006 0.01 § 0.06 § 20 § 
InhibitorIC50 for PKC isoforms, μM
α*βI†βII*γ†δ*ϵ‡ζ*η‡μ†ι/λ†
BIM-I48-50  0.008 0.017 0.016 0.020 0.21 0.132 5.8 § 2 § 
Gö 697648,49,51  0.0023 0.006 0.002-0.0079 0.002-0.006 — — — § 0.02 § 
Gö 698348  0.007 0.007 0.007 0.006 0.01 § 0.06 § 20 § 
*

Expressed in mouse neutrophils.

†

Unknown.

‡

Not expressed in mouse neutrophils.

§

Effect of inhibitor not tested.

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