Table 2 Clonal TCR rearrangements in... | American Society of Hematology

Table 2

Clonal TCR rearrangements in patients with CML at diagnosis and during follow-up samples (n = 18)

Patient no.	Date, ddmmmyy	TCR δ primer pairs						TCR γ primer pairs
Patient no.	Date, ddmmmyy	1	2	3	4	5	6	1	2	3	4	5	6	7	8	9	10	11	12
5
Diagnosis	03MAR05					X*					X*
Dasatinib	11FEB08					X*					X*					X
7
Diagnosis	31MAR09		X*								X	X							X*
Dasatinib	29SEP09		X*																X*
15
Diagnosis	18AUG05
Dasatinib	24JUL08
17
Diagnosis	30MAR09										X
Dasatinib	29SEP09										X		X
21
Diagnosis	12MAR07										X*
Imatinib	14JAN08										X*
22
Diagnosis	15NOV06			X							X	X*
Imatinib	15OCT07											X*
23
Diagnosis	04OCT05								X
Imatinib	01MAR06
24
Diagnosis	03FEB06
Imatinib	13SEP06
25
Diagnosis	26JAN06								X				X
Imatinib	01FEB07
26
Diagnosis	04DEC07
Imatinib	20NOV08
27
Diagnosis	13OCT05																X
Imatinib	12FEB07											X
28
Diagnosis	24MAY05										X
Imatinib	04OCT07								X
29
Diagnosis	20JUL05								X
Imatinib	13MAR07
30
Diagnosis	11JAN07		X					X*
Imatinib	17APR08							X*	X				X
31
Diagnosis	14FEB07							X*
Imatinib	07JAN08							X*
32
Diagnosis	14SEP05											X*						X
Imatinib	20FEB07											X*
33
Diagnosis	19FEB07											X	X			X*
Imatinib	30JUN08															X*
34
Diagnosis	28SEP04		X								X	X*
Imatinib	14SEP05											X*

Patient no.	Date, ddmmmyy	TCR δ primer pairs						TCR γ primer pairs
Patient no.	Date, ddmmmyy	1	2	3	4	5	6	1	2	3	4	5	6	7	8	9	10	11	12
5
Diagnosis	03MAR05					X*					X*
Dasatinib	11FEB08					X*					X*					X
7
Diagnosis	31MAR09		X*								X	X							X*
Dasatinib	29SEP09		X*																X*
15
Diagnosis	18AUG05
Dasatinib	24JUL08
17
Diagnosis	30MAR09										X
Dasatinib	29SEP09										X		X
21
Diagnosis	12MAR07										X*
Imatinib	14JAN08										X*
22
Diagnosis	15NOV06			X							X	X*
Imatinib	15OCT07											X*
23
Diagnosis	04OCT05								X
Imatinib	01MAR06
24
Diagnosis	03FEB06
Imatinib	13SEP06
25
Diagnosis	26JAN06								X				X
Imatinib	01FEB07
26
Diagnosis	04DEC07
Imatinib	20NOV08
27
Diagnosis	13OCT05																X
Imatinib	12FEB07											X
28
Diagnosis	24MAY05										X
Imatinib	04OCT07								X
29
Diagnosis	20JUL05								X
Imatinib	13MAR07
30
Diagnosis	11JAN07		X					X*
Imatinib	17APR08							X*	X				X
31
Diagnosis	14FEB07							X*
Imatinib	07JAN08							X*
32
Diagnosis	14SEP05											X*						X
Imatinib	20FEB07											X*
33
Diagnosis	19FEB07											X	X			X*
Imatinib	30JUN08															X*
34
Diagnosis	28SEP04		X								X	X*
Imatinib	14SEP05											X*

Clonality of the lymphocytes was determined by PCR and gel analysis with the use of 12 primer pairs for the TCR γ gene rearrangements and 6 primer pairs for TCR δ gene rearrangements. Positive clonal PCR products were confirmed with the sequencing and are marked in the columns as X.

Identical rearrangements at the diagnosis and follow-up sample.

View Large

This Feature Is Available To Subscribers Only