Table 5 Vascular phenotypes resulting... | American Society of Hematology

Table 5

Vascular phenotypes resulting from small-molecule treatment of Xenopus embryos (compounds affecting lymph vessel formation only)

Phenotype class/compound name	Pharmacologic class	Selectivity	Blood vessel phenotype	ALS phenotype	ALH phenotype	PLV phenotype	Embryonic phenotype
Defective lymph angiogenesis
Felodipine	Ca²⁺ channel	L-type	Normal	Normal	Dysplastic	Normal	EDE
Sobuzoxane	Gene regulation	Topo II	Normal	Dysplastic	Dysplastic	Hypoplastic	EDE
Nicardipine hydrochloride	Ca²⁺ channel	L-type	Normal	Dysplastic	Dysplastic	Hypoplastic	EDE
SU 6656	Phosphorylation	Src family kinase	Normal	Stunted	Dysplastic	Hypoplastic	EDE
Dequalinium dichloride	K⁺ channel		Normal	Stunted	Stunted	Hypoplastic	EDE
GW2974	Phosphorylation	EGFR/ErbB2-2	Normal	Impaired	Stunted	Hypoplastic	EDE
Mevastatin	Antibiotic	Ras, Rho	Normal	Impaired	Impaired	Hypoplastic	EDE
SU 4312	phosphorylation	KDR	Normal	Impaired	Impaired	Hypoplastic	EDE

Phenotype class/compound name	Pharmacologic class	Selectivity	Blood vessel phenotype	ALS phenotype	ALH phenotype	PLV phenotype	Embryonic phenotype
Defective lymph angiogenesis
Felodipine	Ca²⁺ channel	L-type	Normal	Normal	Dysplastic	Normal	EDE
Sobuzoxane	Gene regulation	Topo II	Normal	Dysplastic	Dysplastic	Hypoplastic	EDE
Nicardipine hydrochloride	Ca²⁺ channel	L-type	Normal	Dysplastic	Dysplastic	Hypoplastic	EDE
SU 6656	Phosphorylation	Src family kinase	Normal	Stunted	Dysplastic	Hypoplastic	EDE
Dequalinium dichloride	K⁺ channel		Normal	Stunted	Stunted	Hypoplastic	EDE
GW2974	Phosphorylation	EGFR/ErbB2-2	Normal	Impaired	Stunted	Hypoplastic	EDE
Mevastatin	Antibiotic	Ras, Rho	Normal	Impaired	Impaired	Hypoplastic	EDE
SU 4312	phosphorylation	KDR	Normal	Impaired	Impaired	Hypoplastic	EDE

Abbreviations are as in Table 3.