Table 4 Vascular phenotypes resulting... | American Society of Hematology

Table 4

Vascular phenotypes resulting from small-molecule treatment of Xenopus embryos (compounds affecting blood and lymph vessel formation)

Phenotype class/compound name	Pharmacologic class	Selectivity	ISV phenotype	VVN phenotype	PCV phenotype	ALS phenotype	ALH phenotype	PLV phenotype	Embryonic phenotype
Defective blood and lymph angiogenesis
Naphthyridine	Adenosine	A1	Stunted	Hypoplastic	Normal	Stunted	Dysplastic	Hypoplastic	EDE
7-Cyclo	Phosphorylation	lck	Stunted	Normal	Normal	Impaired	Impaired	Hypoplastic	EDE
SP600125	Phosphorylation	c-JNK	Stunted	Dysplastic	Normal	Impaired	Impaired	Impaired	LET
VVN hyperplasia and defective lymph angiogenesis
1,3-Diethyl-8-phenylxanthine	Adenosine	A1	Normal	Hyperplastic	Normal	Stunted	Stunted	Hypoplastic	EDE
4-Amino-1,8-naphthalimide	Apoptosis	PARP	Normal	Hyperplastic	Normal	Impaired	Stunted	Hypoplastic	EDE
Genistein	Phosphorylation	Tyrosine kinase	Stunted	Hyperplastic	Normal	Impaired	Impaired	Impaired	EDE

Phenotype class/compound name	Pharmacologic class	Selectivity	ISV phenotype	VVN phenotype	PCV phenotype	ALS phenotype	ALH phenotype	PLV phenotype	Embryonic phenotype
Defective blood and lymph angiogenesis
Naphthyridine	Adenosine	A1	Stunted	Hypoplastic	Normal	Stunted	Dysplastic	Hypoplastic	EDE
7-Cyclo	Phosphorylation	lck	Stunted	Normal	Normal	Impaired	Impaired	Hypoplastic	EDE
SP600125	Phosphorylation	c-JNK	Stunted	Dysplastic	Normal	Impaired	Impaired	Impaired	LET
VVN hyperplasia and defective lymph angiogenesis
1,3-Diethyl-8-phenylxanthine	Adenosine	A1	Normal	Hyperplastic	Normal	Stunted	Stunted	Hypoplastic	EDE
4-Amino-1,8-naphthalimide	Apoptosis	PARP	Normal	Hyperplastic	Normal	Impaired	Stunted	Hypoplastic	EDE
Genistein	Phosphorylation	Tyrosine kinase	Stunted	Hyperplastic	Normal	Impaired	Impaired	Impaired	EDE

Abbreviations are as in Table 3.