Table 1

CI values of ABT-737 at concentrations applied in combination with L-ASP, vincristine, and dexamethasone in ALL cell lines

DrugsABT-737, μMCell lines
CEMCOG-LL-317MOLT-3MOLT-4RS4-11NALM-6COG-LL-319
L-ASP, IU/mL         
    0.1 0.5 0.27 0.24 0.12 0.23 0.10 0.70 0.37 
    0.25 1.25 0.23 0.25 0.18 0.19 0.11 0.60 0.36 
    0.5 2.5 0.17 0.23 0.31 0.21 0.10 0.48 0.26 
    1.0 5 0.20 0.29 0.56 0.42 0.21 0.31 0.23 
    Mean — 0.22 0.25 0.29 0.26 0.13 0.52 0.31 
VCR, ng/mL         
    5 0.5 0.04 0.13 0.42 0.42 0.08 0.86 0.52 
    12.5 1.25 0.08 0.10 0.27 0.35 0.15 0.93 0.40 
    25 2.5 0.10 0.07 0.53 0.59 0.19 0.67 0.28 
    50 5 0.15 0.09 1.06 1.42 0.30 1.21 0.37 
    Mean — 0.09 0.10 0.57 0.70 0.18 0.92 0.39 
Dex, nM         
    50 0.5 0.23 0.17 0.83 0.65 0.21 0.33 0.46 
    125 1.25 0.21 0.32 0.88 0.86 0.41 0.37 0.55 
    250 2.5 0.26 0.54 0.65 0.70 0.52 0.45 0.72 
    500 5 0.34 0.60 0.89 0.62 0.75 0.44 1.13 
    Mean — 0.26 0.41 0.81 0.71 0.47 0.40 0.72 
DrugsABT-737, μMCell lines
CEMCOG-LL-317MOLT-3MOLT-4RS4-11NALM-6COG-LL-319
L-ASP, IU/mL         
    0.1 0.5 0.27 0.24 0.12 0.23 0.10 0.70 0.37 
    0.25 1.25 0.23 0.25 0.18 0.19 0.11 0.60 0.36 
    0.5 2.5 0.17 0.23 0.31 0.21 0.10 0.48 0.26 
    1.0 5 0.20 0.29 0.56 0.42 0.21 0.31 0.23 
    Mean — 0.22 0.25 0.29 0.26 0.13 0.52 0.31 
VCR, ng/mL         
    5 0.5 0.04 0.13 0.42 0.42 0.08 0.86 0.52 
    12.5 1.25 0.08 0.10 0.27 0.35 0.15 0.93 0.40 
    25 2.5 0.10 0.07 0.53 0.59 0.19 0.67 0.28 
    50 5 0.15 0.09 1.06 1.42 0.30 1.21 0.37 
    Mean — 0.09 0.10 0.57 0.70 0.18 0.92 0.39 
Dex, nM         
    50 0.5 0.23 0.17 0.83 0.65 0.21 0.33 0.46 
    125 1.25 0.21 0.32 0.88 0.86 0.41 0.37 0.55 
    250 2.5 0.26 0.54 0.65 0.70 0.52 0.45 0.72 
    500 5 0.34 0.60 0.89 0.62 0.75 0.44 1.13 
    Mean — 0.26 0.41 0.81 0.71 0.47 0.40 0.72 

A CI less than 0.9 indicates synergism; 0.1, very strong synergism; 0.1 to 0.3, strong synergism; 0.3 to 0.7, synergism; 0.7 to 0.85, moderate synergism; 0.85 to 0.9, slight synergism; 0.9 to 1.10, additive; and more than 1.10, antagonism.

— indicates not applicable.

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