Potential adverse consequences of thrombopoietic growth factor treatment
| Thrombocytosis |
| Thrombosis |
| Stimulation of tumor cell growth |
| Stimulation of leukemia cell growth |
| Interactions with other cytokines |
| Autoantibody formation |
| Stem cell depletion |
| Reduction in threshold for platelet activation |
| Increased bone marrow reticulin (positive reticulin stain) |
| Increased bone marrow collagen (positive trichrome stain) |
| Rebound worsening of thrombocytopenia upon stopping treatment |
| Thrombocytosis |
| Thrombosis |
| Stimulation of tumor cell growth |
| Stimulation of leukemia cell growth |
| Interactions with other cytokines |
| Autoantibody formation |
| Stem cell depletion |
| Reduction in threshold for platelet activation |
| Increased bone marrow reticulin (positive reticulin stain) |
| Increased bone marrow collagen (positive trichrome stain) |
| Rebound worsening of thrombocytopenia upon stopping treatment |