Prophylaxis regimens and treatments for chronic GVHD
| Randomized trial . | Main results on chronic GVHD . | Reference . |
|---|---|---|
| Acute GVHD prophylaxis | ||
| Calcineurin inhibitors +/– methotrexate | No effect | 10, 76 |
| Prolonged cyclosporine | No effect | 10, 76 |
| Ex vivo T-cell depletion | No effect | 10, 76, 77 |
| Antithymocyte globulin | Decreased incidence | 72-75 |
| First-line treatment | ||
| Prednisone +/– azathioprine | Prednisone better | 79 |
| Prednisone + cyclosporine vs prednisone | Reduced prednisone exposure with combination | 80 |
| Prednisone + cyclosporine vs prednisone + cyclosporine + thalidomide | No benefit of thalidomide | 81, 82 |
| Prednisone + cyclosporine vs prednisone + cyclosporine + mycophenolate mofetil | No benefit of mycophenolate mofetil | 83 |
| Prednisone +cyclosporine vs prednisone +cyclosporine + hydroxychloroquine | No benefit of hydroxychloroquine | 84 |
| Randomized trial . | Main results on chronic GVHD . | Reference . |
|---|---|---|
| Acute GVHD prophylaxis | ||
| Calcineurin inhibitors +/– methotrexate | No effect | 10, 76 |
| Prolonged cyclosporine | No effect | 10, 76 |
| Ex vivo T-cell depletion | No effect | 10, 76, 77 |
| Antithymocyte globulin | Decreased incidence | 72-75 |
| First-line treatment | ||
| Prednisone +/– azathioprine | Prednisone better | 79 |
| Prednisone + cyclosporine vs prednisone | Reduced prednisone exposure with combination | 80 |
| Prednisone + cyclosporine vs prednisone + cyclosporine + thalidomide | No benefit of thalidomide | 81, 82 |
| Prednisone + cyclosporine vs prednisone + cyclosporine + mycophenolate mofetil | No benefit of mycophenolate mofetil | 83 |
| Prednisone +cyclosporine vs prednisone +cyclosporine + hydroxychloroquine | No benefit of hydroxychloroquine | 84 |