Table 1 Signs and symptoms of chronic... | American Society of Hematology

Table 1

Signs and symptoms of chronic GVHD

Organ or site	Diagnostic (sufficient for diagnosis)	Distinctive (insufficient alone for diagnosis)	Common (seen in both acute and chronic GVHD)
Skin	Poikiloderma, lichen planus-like, sclerosis or morphea	Depigmentation	Erythema, maculopapular rash
Nails		Dystrophy, onycholysis/nail loss
Scalp and body hair		Alopecia, scaling
Mouth	Lichen planus-like, hyperkeratotic plaques	Xerostomia, mucocele, ulcers, pseudomembrane*	Gingivitis, erythema
Eyes		Keratoconjunctivitis,* Sicca syndrome
Genitalia	Lichen planus-like, vaginal scarring or stenosis	Erosions,* fissures,* ulcers*
Gastrointestinal tract	Esophageal web or stenosis*		Anorexia/nausea, diarrhea
Liver			Mixed hepatitis
Lung	BO by lung biopsy	BO diagnosed by pulmonary function tests and radiology	BOOP
Muscle and fascia	Fasciitis, joint contractures	Myositis and polymyositis
Hematopoietic			Thrombocytopenia, eosinophilia, hypo or hypergammaglobulinemia, autoantibodies
Other			Effusions†

Organ or site	Diagnostic (sufficient for diagnosis)	Distinctive (insufficient alone for diagnosis)	Common (seen in both acute and chronic GVHD)
Skin	Poikiloderma, lichen planus-like, sclerosis or morphea	Depigmentation	Erythema, maculopapular rash
Nails		Dystrophy, onycholysis/nail loss
Scalp and body hair		Alopecia, scaling
Mouth	Lichen planus-like, hyperkeratotic plaques	Xerostomia, mucocele, ulcers, pseudomembrane*	Gingivitis, erythema
Eyes		Keratoconjunctivitis,* Sicca syndrome
Genitalia	Lichen planus-like, vaginal scarring or stenosis	Erosions,* fissures,* ulcers*
Gastrointestinal tract	Esophageal web or stenosis*		Anorexia/nausea, diarrhea
Liver			Mixed hepatitis
Lung	BO by lung biopsy	BO diagnosed by pulmonary function tests and radiology	BOOP
Muscle and fascia	Fasciitis, joint contractures	Myositis and polymyositis
Hematopoietic			Thrombocytopenia, eosinophilia, hypo or hypergammaglobulinemia, autoantibodies
Other			Effusions†

Simplified from Filipovich et al.⁴

In all cases, infection, drug side effects, and malignancy must be excluded.

Pericardial, pleural, or ascites.