Examples of RIC and nonmyeloablative regimens according to commonly used agents and combinations
| RIC regimens . | Nonmyeloblative regimens . |
|---|---|
| TBI ≤500 cGy as a single fraction or ≤800 cGy if fractionated | FLU + CY + ATG |
| Total BU ≤9 mg/kg | FLU + AraC + Ida |
| Total MEL <140 mg/m2 | Cladribine + AraC |
| Thiotepa <10 mg/kg | Total lymphoid irradiation + ATG |
| TBI ≤2 Gy ± purine analog |
| RIC regimens . | Nonmyeloblative regimens . |
|---|---|
| TBI ≤500 cGy as a single fraction or ≤800 cGy if fractionated | FLU + CY + ATG |
| Total BU ≤9 mg/kg | FLU + AraC + Ida |
| Total MEL <140 mg/m2 | Cladribine + AraC |
| Thiotepa <10 mg/kg | Total lymphoid irradiation + ATG |
| TBI ≤2 Gy ± purine analog |
Adapted from Giralt et al.104,105 AraC, cytarabine; ATG, antithymocyte globulin; BU, busulfan; CY, cyclophosphamide; FLU, fludarabine; Ida, idarubicin; MEL, melphalan.