Dose number and drug-related adverse events
| Patient no. . | No. doses received . | Drug-related adverse effects (CTCAE v4.03 toxicity grade) . |
|---|---|---|
| 1 | 5 | Gr 2 chills, Gr 2 fever, Gr 1 nausea, Gr 3 AST, Gr 1 ALT, Gr 2 hypoalbuminemia, |
| 1B | 5 | None |
| 2 | 3 | Gr 1 fever, Gr 2 hypoalbuminemia, Gr 1 thrombocytopenia, Gr 2 edema |
| 3 | 5 | Gr 2 chills, Gr 2 fever, headache, Gr 3 AST, Gr 2 ALT, Gr 1 hypoalbuminemia, Gr 1 tachycardia, Gr 1 facial flushing |
| 4 | 5 | Gr 1 edema, Gr 2 hypoalbuminemia, Gr 3 thrombocytopenia, Gr 3 neutropenia, Gr 1 AST, Gr 1 ALT |
| 5 | 5 | Gr 1 fever, Gr 1 fatigue, Gr 1 hypoalbuminemia, Gr 2 thrombocytopenia, Gr 2 AST, Gr 2 ALT |
| 5B | 5 | Gr 1 thrombocytopenia, Gr 1 hypoalbuminemia |
| 6 | 5 | Gr 4 thrombocytopenia, Gr 2 hypoalbuminemia, Gr 1 hypocalcemia |
| 7 | 5 | Gr 3 AST, Gr 3 ALT, Gr 3 thrombocytopenia, Gr 4 hyponatremia, Gr 1 nausea, Gr1 anorexia, Gr 1 edema |
| 8 | 1 | Gr 2 uremia/elevated creatinine, Gr 1 hypotension, Gr 3 thrombocytopenia, Gr 1 ALT, Gr 1 AST |
| 8B | 2 | Gr 1 elevated prothrombin time, Gr 2 thrombocytopenia, Gr 2 neutropenia, Gr 1 anemia, Gr 1 uremia |
| 9 | 2 | Gr 3 ALT, Gr 2 AST, Gr 3 thrombocytopenia, Gr 1 nausea, Gr 1 hypoalbuminemia, Gr 1 fever, Gr 1 chills |
| 10 | 5 | Gr 3 ALT, Gr 3 AST, Gr 3 thrombocytopenia, Gr 1 anemia, Gr 2 nausea, Gr 1 hyponatremia, Gr 2 nausea, Gr 1 anorexia, Gr 2 fatigue, Gr 1 hypocalcemia, Gr 2 hypoalbuminemia |
| 11 | 1 | Gr 2 hypoalbuminemia, Gr 1 ALT |
| Patient no. . | No. doses received . | Drug-related adverse effects (CTCAE v4.03 toxicity grade) . |
|---|---|---|
| 1 | 5 | Gr 2 chills, Gr 2 fever, Gr 1 nausea, Gr 3 AST, Gr 1 ALT, Gr 2 hypoalbuminemia, |
| 1B | 5 | None |
| 2 | 3 | Gr 1 fever, Gr 2 hypoalbuminemia, Gr 1 thrombocytopenia, Gr 2 edema |
| 3 | 5 | Gr 2 chills, Gr 2 fever, headache, Gr 3 AST, Gr 2 ALT, Gr 1 hypoalbuminemia, Gr 1 tachycardia, Gr 1 facial flushing |
| 4 | 5 | Gr 1 edema, Gr 2 hypoalbuminemia, Gr 3 thrombocytopenia, Gr 3 neutropenia, Gr 1 AST, Gr 1 ALT |
| 5 | 5 | Gr 1 fever, Gr 1 fatigue, Gr 1 hypoalbuminemia, Gr 2 thrombocytopenia, Gr 2 AST, Gr 2 ALT |
| 5B | 5 | Gr 1 thrombocytopenia, Gr 1 hypoalbuminemia |
| 6 | 5 | Gr 4 thrombocytopenia, Gr 2 hypoalbuminemia, Gr 1 hypocalcemia |
| 7 | 5 | Gr 3 AST, Gr 3 ALT, Gr 3 thrombocytopenia, Gr 4 hyponatremia, Gr 1 nausea, Gr1 anorexia, Gr 1 edema |
| 8 | 1 | Gr 2 uremia/elevated creatinine, Gr 1 hypotension, Gr 3 thrombocytopenia, Gr 1 ALT, Gr 1 AST |
| 8B | 2 | Gr 1 elevated prothrombin time, Gr 2 thrombocytopenia, Gr 2 neutropenia, Gr 1 anemia, Gr 1 uremia |
| 9 | 2 | Gr 3 ALT, Gr 2 AST, Gr 3 thrombocytopenia, Gr 1 nausea, Gr 1 hypoalbuminemia, Gr 1 fever, Gr 1 chills |
| 10 | 5 | Gr 3 ALT, Gr 3 AST, Gr 3 thrombocytopenia, Gr 1 anemia, Gr 2 nausea, Gr 1 hyponatremia, Gr 2 nausea, Gr 1 anorexia, Gr 2 fatigue, Gr 1 hypocalcemia, Gr 2 hypoalbuminemia |
| 11 | 1 | Gr 2 hypoalbuminemia, Gr 1 ALT |
ALT, alanine transaminase; AST, asparate transaminase; B, second course; Gr, grade.