Expression of BCL-6, Syn-1, and LMP-1 in HD
| Case . | Diagnosis . | Phenotype . | BCL-6 (%)-150 . | Syn-1 (%)-150 . | LMP-1 (%)-150 . |
|---|---|---|---|---|---|
| 1 | NLP HD | B | >75 | 0 | 0 |
| 2 | NLP HD | B | >75 | 0 | 0 |
| 3 | NLP HD | B | >75 | 0 | 0 |
| 4 | NLP HD | B | >75 | 0 | 0 |
| 5 | NLP HD | B | >75 | 0 | 0 |
| 6 | NLP HD | B | >75 | 0 | 0 |
| 7 | NLP HD | B | >75 | 0 | 0 |
| 8 | NLP HD | B | >75 | 0 | 0 |
| 9 | NLP HD | B | >75 | 0 | 0 |
| 10 | NLP HD | B | >75 | 0 | 0 |
| 11 | MC HD | Undetermined | <10 | <10 | 10-25 |
| 12 | MC HD | Undetermined | <10 | <10 | 25-50 |
| 13 | MC HD | Undetermined | <10 | 10-25 | 0 |
| 14 | MC HD | Undetermined | <10 | 10-25 | 25-50 |
| 15 | MC HD | Undetermined | 0 | <10 | <10 |
| 16 | MC HD | Undetermined | 0 | 25-50 | 0 |
| 17 | MC HD | Undetermined | 0 | 25-50 | 0 |
| 18 | MC HD | Undetermined | 0 | 25-50 | 50-75 |
| 19 | MC HD | Undetermined | 0 | 25-50 | 10-25 |
| 20 | MC HD | Undetermined | 0 | 50-75 | 0 |
| 21 | MC HD | B | 0 | 10-25 | 50-75 |
| 22 | MC HD | B | 0 | >75 | 0 |
| 23 | NS HD | Undetermined | 10-25 | 25-50 | 50-75 |
| 24 | NS HD | Undetermined | 10-25 | 50-75 | 0 |
| 25 | NS HD | Undetermined | 10-25 | 50-75 | 0 |
| 26 | NS HD | Undetermined | 10-25 | 50-75 | 0 |
| 27 | NS HD | Undetermined | <10 | 10-25 | 0 |
| 28 | NS HD | Undetermined | <10 | 25-50 | 0 |
| 29 | NS HD | Undetermined | <10 | 25-50 | 0 |
| 30 | NS HD | Undetermined | <10 | 25-50 | 0 |
| 31 | NS HD | Undetermined | <10 | 50-75 | 0 |
| 32 | NS HD | Undetermined | <10 | 50-75 | 0 |
| 33 | NS HD | Undetermined | <10 | 50-75 | 0 |
| 34 | NS HD | Undetermined | 0 | <10 | 0 |
| 35 | NS HD | Undetermined | 0 | 10-25 | 0 |
| 36 | NS HD | Undetermined | 0 | 10-25 | 0 |
| 37 | NS HD | Undetermined | 0 | 10-25 | 0 |
| 38 | NS HD | Undetermined | 0 | 10-25 | 50-75 |
| 39 | NS HD | Undetermined | 0 | 25-50 | 0 |
| 40 | NS HD | Undetermined | 0 | 25-50 | 0 |
| 41 | NS HD | Undetermined | 0 | 25-50 | 0 |
| 42 | NS HD | Undetermined | 0 | 50-75 | 0 |
| 43 | NS HD | Undetermined | 0 | 50-75 | 0 |
| 44 | NS HD | Undetermined | 0 | 50-75 | 0 |
| 45 | NS HD | Undetermined | 0 | >75 | 0 |
| 46 | NS HD | B | <10 | <10 | 0 |
| 47 | NS HD | B | <10 | 50-75 | 0 |
| 48 | NS HD | B | <10 | >75 | 0 |
| 49 | NS HD | B | 0 | 10-25 | 0 |
| 50 | NS HD | B | 0 | 10-25 | 0 |
| 51 | NS HD | B | 0 | 10-25 | 0 |
| 52 | NS HD | B | 0 | 50-75 | 0 |
| 53 | NS HD | B | 0 | 50-75 | 0 |
| Case . | Diagnosis . | Phenotype . | BCL-6 (%)-150 . | Syn-1 (%)-150 . | LMP-1 (%)-150 . |
|---|---|---|---|---|---|
| 1 | NLP HD | B | >75 | 0 | 0 |
| 2 | NLP HD | B | >75 | 0 | 0 |
| 3 | NLP HD | B | >75 | 0 | 0 |
| 4 | NLP HD | B | >75 | 0 | 0 |
| 5 | NLP HD | B | >75 | 0 | 0 |
| 6 | NLP HD | B | >75 | 0 | 0 |
| 7 | NLP HD | B | >75 | 0 | 0 |
| 8 | NLP HD | B | >75 | 0 | 0 |
| 9 | NLP HD | B | >75 | 0 | 0 |
| 10 | NLP HD | B | >75 | 0 | 0 |
| 11 | MC HD | Undetermined | <10 | <10 | 10-25 |
| 12 | MC HD | Undetermined | <10 | <10 | 25-50 |
| 13 | MC HD | Undetermined | <10 | 10-25 | 0 |
| 14 | MC HD | Undetermined | <10 | 10-25 | 25-50 |
| 15 | MC HD | Undetermined | 0 | <10 | <10 |
| 16 | MC HD | Undetermined | 0 | 25-50 | 0 |
| 17 | MC HD | Undetermined | 0 | 25-50 | 0 |
| 18 | MC HD | Undetermined | 0 | 25-50 | 50-75 |
| 19 | MC HD | Undetermined | 0 | 25-50 | 10-25 |
| 20 | MC HD | Undetermined | 0 | 50-75 | 0 |
| 21 | MC HD | B | 0 | 10-25 | 50-75 |
| 22 | MC HD | B | 0 | >75 | 0 |
| 23 | NS HD | Undetermined | 10-25 | 25-50 | 50-75 |
| 24 | NS HD | Undetermined | 10-25 | 50-75 | 0 |
| 25 | NS HD | Undetermined | 10-25 | 50-75 | 0 |
| 26 | NS HD | Undetermined | 10-25 | 50-75 | 0 |
| 27 | NS HD | Undetermined | <10 | 10-25 | 0 |
| 28 | NS HD | Undetermined | <10 | 25-50 | 0 |
| 29 | NS HD | Undetermined | <10 | 25-50 | 0 |
| 30 | NS HD | Undetermined | <10 | 25-50 | 0 |
| 31 | NS HD | Undetermined | <10 | 50-75 | 0 |
| 32 | NS HD | Undetermined | <10 | 50-75 | 0 |
| 33 | NS HD | Undetermined | <10 | 50-75 | 0 |
| 34 | NS HD | Undetermined | 0 | <10 | 0 |
| 35 | NS HD | Undetermined | 0 | 10-25 | 0 |
| 36 | NS HD | Undetermined | 0 | 10-25 | 0 |
| 37 | NS HD | Undetermined | 0 | 10-25 | 0 |
| 38 | NS HD | Undetermined | 0 | 10-25 | 50-75 |
| 39 | NS HD | Undetermined | 0 | 25-50 | 0 |
| 40 | NS HD | Undetermined | 0 | 25-50 | 0 |
| 41 | NS HD | Undetermined | 0 | 25-50 | 0 |
| 42 | NS HD | Undetermined | 0 | 50-75 | 0 |
| 43 | NS HD | Undetermined | 0 | 50-75 | 0 |
| 44 | NS HD | Undetermined | 0 | 50-75 | 0 |
| 45 | NS HD | Undetermined | 0 | >75 | 0 |
| 46 | NS HD | B | <10 | <10 | 0 |
| 47 | NS HD | B | <10 | 50-75 | 0 |
| 48 | NS HD | B | <10 | >75 | 0 |
| 49 | NS HD | B | 0 | 10-25 | 0 |
| 50 | NS HD | B | 0 | 10-25 | 0 |
| 51 | NS HD | B | 0 | 10-25 | 0 |
| 52 | NS HD | B | 0 | 50-75 | 0 |
| 53 | NS HD | B | 0 | 50-75 | 0 |
RS cells and variants of all HD cases expressed CD40 antigen in percentages ranging from 50% to 75%.
Abbreviations: MC, mixed cellularity; NS, nodular sclerosis.
The percentage of BCL-6, syn-1, and LMP-1 positive neoplastic cells was assigned to one of the following categories: 0, <10%, 10% to 25%, 25% to 50%, 50% to 75%, and >75%.