Table 2. Data in Dogs Administered 9.2... | American Society of Hematology

Table 2.

Data in Dogs Administered 9.2 Gy TBI and Infusion of DLA-Nonidentical Unrelated Bone Marrow Grafts After Treatment of Marrow Recipients With Intravenous Injection of MoAbs S5, IM7, or S3

MoAb	Recipient No.	Marrow Cell No. Infused (×10⁸/kg)	Increase in WBC ≥500/mm³ After Transplant	Marrow Cellularity at Autopsy (% of normal)	GVHD		Sustained Graft	Survival (d)	Cause of Death
MoAb	Recipient No.	Marrow Cell No. Infused (×10⁸/kg)	Increase in WBC ≥500/mm³ After Transplant	Marrow Cellularity at Autopsy (% of normal)	Clinical	Histological	Sustained Graft	Survival (d)	Cause of Death
S5	C202^*^,^†	2.4	No	0	No	No	No	11	Graft failure, sepsis
	C209^*^,^†	2.6	No	0	No	No	No	10	Graft failure, sepsis
	B821^*^,^†	4.2	Yes	100	Skin	Skin	Yes	30	GVHD, sepsis
	C171^*^,^†	3.2	Yes	20	Skin, gut	Skin, gut	Yes	16	GVHD, pneumonia
	B864^*^,^†	6.5	Yes	70	Skin, gut	Skin, gut, liver	Yes	14	GVHD, sepsis
	C231^*^,^‡	3.8	No	0	No	No	No	14	Graft failure, pneumonia
	C253^*^,^‡	4.1	Yes	0	No	No	No	13	Graft failure, pneumonia
	C249^*^,^‡	4.3	No	0	No	Skin, gut	No	13	Graft failure, sepsis
	C213^*^,^‡	2.6	Yes	25	Skin, gut	Skin, liver	Yes	9	GVHD, sepsis
	C197^*^,^‡	4.2	Yes	5	Skin, gut, liver	Skin, liver	Yes	19	GVHD, pneumonia
	C226^*^,^‡	4.1	Yes	80	Skin, gut	Skin, gut, liver	Yes	11	GVHD, pneumonia
	C218^*^,^‡	1.6	Yes	60	Skin, gut, liver	Skin	Yes	18	GVHD, pneumonia
	C254^*^,^‡	2.8	Yes	60	No	Gut	Yes	10	GVHD, pneumonia
	C258^*^,^‡	4.8	Yes	100	Skin	Skin, gut	Yes	11	GVHD, pneumonia
	C247^*^,^‡	2.3	Yes	60	Skin, gut	Skin, gut, liver	Yes	8	GVHD, pneumonia
	D291^‡	4.0	Yes	60	No	Gut	Yes	10	Intussusception
	D444^‡	3.0	No	0	No	No	No	13	Graft failure, pneumonia
	D450^‡	1.9	No	0	No	Skin, gut	No	14	Graft failure, pneumonia
	C598^1-153	4.4	Yes	25	Skin, gut	Skin, gut	Yes	13	GVHD, dehydration
	C646^1-153	3.2	Yes	100	Skin, gut, liver	No	Yes	21	GVHD
	C712^1-153	4.5	Yes	50	Skin, liver	Skin, gut	Yes	20	GVHD
IM7^1-155	D109	4.3	Yes	70	Skin, gut	Skin, gut	Yes	14	GVHD
	D115	4.0	No	<2	No	No	No	10	Graft failure, pneumonia
	D153	4.1	Yes	<2	No	Skin	No	20	Graft failure
	D161	4.0	No	0	No	Skin, gut	No	13	Graft failure, pneumonia
	D173	3.2	No	1	No	No	No	13	Graft failure, pneumonia
S3^1-155	C388	3.7	No	0	No	Gut	No	15	Graft failure, pneumonia
	C433	1.3	No	Early focal	No	No	No	14	Graft failure, pneumonia
	C436	4.1	Yes	25	Skin, gut	Skin, gut, liver	Yes	21	Pneumonia
	C439	4.1	No	0	No	No	No	17	Graft failure, pneumonia
	C441	4.1	Yes	0	No	No	No	12	Graft failure
	C445	4.0	No	0	No	No	No	12	Graft failure, pneumonia
	C454	4.6	Yes	25	Skin, gut	Gut	Yes	17	GVHD, pneumonia
	C952	3.2	No	0	No	No	No	11	Graft failure, pneumonia
	C962	1.8	Yes	25	Skin	Skin, liver	Yes	13	Pneumonia
	C968	4.0	Yes	0	No	No	No	12	Graft failure
	C983	4.0	Yes	0	No	No	No	28	Graft failure, sepsis

MoAb	Recipient No.	Marrow Cell No. Infused (×10⁸/kg)	Increase in WBC ≥500/mm³ After Transplant	Marrow Cellularity at Autopsy (% of normal)	GVHD		Sustained Graft	Survival (d)	Cause of Death
MoAb	Recipient No.	Marrow Cell No. Infused (×10⁸/kg)	Increase in WBC ≥500/mm³ After Transplant	Marrow Cellularity at Autopsy (% of normal)	Clinical	Histological	Sustained Graft	Survival (d)	Cause of Death
S5	C202^*^,^†	2.4	No	0	No	No	No	11	Graft failure, sepsis
	C209^*^,^†	2.6	No	0	No	No	No	10	Graft failure, sepsis
	B821^*^,^†	4.2	Yes	100	Skin	Skin	Yes	30	GVHD, sepsis
	C171^*^,^†	3.2	Yes	20	Skin, gut	Skin, gut	Yes	16	GVHD, pneumonia
	B864^*^,^†	6.5	Yes	70	Skin, gut	Skin, gut, liver	Yes	14	GVHD, sepsis
	C231^*^,^‡	3.8	No	0	No	No	No	14	Graft failure, pneumonia
	C253^*^,^‡	4.1	Yes	0	No	No	No	13	Graft failure, pneumonia
	C249^*^,^‡	4.3	No	0	No	Skin, gut	No	13	Graft failure, sepsis
	C213^*^,^‡	2.6	Yes	25	Skin, gut	Skin, liver	Yes	9	GVHD, sepsis
	C197^*^,^‡	4.2	Yes	5	Skin, gut, liver	Skin, liver	Yes	19	GVHD, pneumonia
	C226^*^,^‡	4.1	Yes	80	Skin, gut	Skin, gut, liver	Yes	11	GVHD, pneumonia
	C218^*^,^‡	1.6	Yes	60	Skin, gut, liver	Skin	Yes	18	GVHD, pneumonia
	C254^*^,^‡	2.8	Yes	60	No	Gut	Yes	10	GVHD, pneumonia
	C258^*^,^‡	4.8	Yes	100	Skin	Skin, gut	Yes	11	GVHD, pneumonia
	C247^*^,^‡	2.3	Yes	60	Skin, gut	Skin, gut, liver	Yes	8	GVHD, pneumonia
	D291^‡	4.0	Yes	60	No	Gut	Yes	10	Intussusception
	D444^‡	3.0	No	0	No	No	No	13	Graft failure, pneumonia
	D450^‡	1.9	No	0	No	Skin, gut	No	14	Graft failure, pneumonia
	C598^1-153	4.4	Yes	25	Skin, gut	Skin, gut	Yes	13	GVHD, dehydration
	C646^1-153	3.2	Yes	100	Skin, gut, liver	No	Yes	21	GVHD
	C712^1-153	4.5	Yes	50	Skin, liver	Skin, gut	Yes	20	GVHD
IM7^1-155	D109	4.3	Yes	70	Skin, gut	Skin, gut	Yes	14	GVHD
	D115	4.0	No	<2	No	No	No	10	Graft failure, pneumonia
	D153	4.1	Yes	<2	No	Skin	No	20	Graft failure
	D161	4.0	No	0	No	Skin, gut	No	13	Graft failure, pneumonia
	D173	3.2	No	1	No	No	No	13	Graft failure, pneumonia
S3^1-155	C388	3.7	No	0	No	Gut	No	15	Graft failure, pneumonia
	C433	1.3	No	Early focal	No	No	No	14	Graft failure, pneumonia
	C436	4.1	Yes	25	Skin, gut	Skin, gut, liver	Yes	21	Pneumonia
	C439	4.1	No	0	No	No	No	17	Graft failure, pneumonia
	C441	4.1	Yes	0	No	No	No	12	Graft failure
	C445	4.0	No	0	No	No	No	12	Graft failure, pneumonia
	C454	4.6	Yes	25	Skin, gut	Gut	Yes	17	GVHD, pneumonia
	C952	3.2	No	0	No	No	No	11	Graft failure, pneumonia
	C962	1.8	Yes	25	Skin	Skin, liver	Yes	13	Pneumonia
	C968	4.0	Yes	0	No	No	No	12	Graft failure
	C983	4.0	Yes	0	No	No	No	28	Graft failure, sepsis

*Data on these dogs were previously reported.

†

MoAb S5 days −5 to 0, 0.2 mg/kg/d.

‡

MoAb S5 days −7 to −2, 0.2 mg/kg/d.

F1-153

MoAb S5 days −7 to −2, 0.2 mg/kg/d with the day −7 MoAb¹³¹I-iodinated (dose equivalent to 100 cGy external beam TBI).

F1-155

MoAb was administered 0.2 mg/kg/d days −7 to −2.

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