Table 3. Effects of Cytokines and Other... | American Society of Hematology

Table 3.

Effects of Cytokines and Other Agents on Clonogenic Growth of KS-1 and BC-1 Cell Lines

Cytokines and Other Agents	Effect on Clonal Growth of PEL Cell Lines
Cytokines and Other Agents	KS-1	BC-1
Human IL-6 antisense	Inhibition	Inhibition
(10 μmol/L)	(95%)^*	(98%)^*
Viral IL-6 antisense	NE	NE
(1 to 10 μmol/L)
Human IL-10^†	NE	NE
Human IL-10 antisense	NE	NE
IFN-α	Inhibition	NE
(1,000 U/mL)	(99%)^*
IFN-γ	Inhibition	NE
(1,000 U/mL)	(48%)^*
IL-6^†	NE	NE
GM-CSF^†	NE	NT
Oncostatin M^†	NE	NT
IL-4^†	NE	NE
IL-8^†	NE	NE
ATRA^†	NE	NT
hCG α and β^†	NE	NT

Cytokines and Other Agents	Effect on Clonal Growth of PEL Cell Lines
Cytokines and Other Agents	KS-1	BC-1
Human IL-6 antisense	Inhibition	Inhibition
(10 μmol/L)	(95%)^*	(98%)^*
Viral IL-6 antisense	NE	NE
(1 to 10 μmol/L)
Human IL-10^†	NE	NE
Human IL-10 antisense	NE	NE
IFN-α	Inhibition	NE
(1,000 U/mL)	(99%)^*
IFN-γ	Inhibition	NE
(1,000 U/mL)	(48%)^*
IL-6^†	NE	NE
GM-CSF^†	NE	NT
Oncostatin M^†	NE	NT
IL-4^†	NE	NE
IL-8^†	NE	NE
ATRA^†	NE	NT
hCG α and β^†	NE	NT

Abbreviations: NE, no effect; NT, not tested.

% of inhibition.

Concentration and exposure duration provided in Materials and Methods.