Table 1. Expression of HOXC4, HOXC5, and... | American Society of Hematology

Table 1.

Expression of HOXC4, HOXC5, and HOXC6 in T-NHL, Classified According to Updated Kiel Classification With Some Modifications According to REAL Classification

Case No.	Biopsy Site	RISH			RT-PCR
		C4	C5	C6	C4	C5	C6
Mycosis fungoides
1	Skin arm plaque	+	−	+	+	+	+
2	Skin abdomen plaque	+	−	±
3	Skin head tumor	+	−	+
4	Skin back tumor	−	−	+	+	+	+
5	Skin head tumor	+	−	+
6	LN neck	+	−	+	+	+	+
7	LN armpit	+	−	+
Pleomorphic T-cell lymphoma small
8	Nose	±	−	±
Pleomorphic T-cell lymphoma medium/large
9	Skin nose	+	−	+
10	LN neck	+	−	+
11	LN neck	+	−	+
12	LN neck	±	−	+	+	−	+
13	LN supraclavicular	+	−	+
14	LN inguinal	+	−	+
15	Nose	+	−	−	+	ND	−
16	Gut duodenum	+	+	+
17	Gut duodenum	+	+	+
18	Gut duodenum	+	NE	+
19	Skin cheek	+	−	±
20	Skin upper leg	+	−	+
21	Gut duodenum	±	−	−
22	Gut duodenum	−	−	±
ALCL
23	Skin face	+	+	+	+	+	+
24	Skin armpit	+	+	+
25	Skin armpit	+	±	+
26	Skin arm	±	+	+	+	+	+
27	Skin arm	+	+	+	+	+	+
28	Skin abdomen	+	+	±
29	Skin abdomen	+	+	+
30	Skin back	+	+	+	+	+	+
31	Skin leg	+	+	+
32	LN neck	−	NE	+	+	+	+
33	LN armpit	+	+	+
34	LN armpit	±	−	+
35	LN armpit	±	−	+
36	LN armpit	+	+	+
37	LN abdomen	±	−	+
38	LN inguinal	+	−	+
39^*	LN inguinal	−	+	+	−	+	+
40	LN retroperitoneal	+	−	+
41	Gut duodenum	+	NE	+
Angioimmunoblastic lymphadenopathy with dysproteinemia
42	LN supraclavicular	+	−	+	+	−	+
Immunoblastic T-cell lymphoma
43	Skin upper arm	+	−	+

Case No.	Biopsy Site	RISH			RT-PCR
		C4	C5	C6	C4	C5	C6
Mycosis fungoides
1	Skin arm plaque	+	−	+	+	+	+
2	Skin abdomen plaque	+	−	±
3	Skin head tumor	+	−	+
4	Skin back tumor	−	−	+	+	+	+
5	Skin head tumor	+	−	+
6	LN neck	+	−	+	+	+	+
7	LN armpit	+	−	+
Pleomorphic T-cell lymphoma small
8	Nose	±	−	±
Pleomorphic T-cell lymphoma medium/large
9	Skin nose	+	−	+
10	LN neck	+	−	+
11	LN neck	+	−	+
12	LN neck	±	−	+	+	−	+
13	LN supraclavicular	+	−	+
14	LN inguinal	+	−	+
15	Nose	+	−	−	+	ND	−
16	Gut duodenum	+	+	+
17	Gut duodenum	+	+	+
18	Gut duodenum	+	NE	+
19	Skin cheek	+	−	±
20	Skin upper leg	+	−	+
21	Gut duodenum	±	−	−
22	Gut duodenum	−	−	±
ALCL
23	Skin face	+	+	+	+	+	+
24	Skin armpit	+	+	+
25	Skin armpit	+	±	+
26	Skin arm	±	+	+	+	+	+
27	Skin arm	+	+	+	+	+	+
28	Skin abdomen	+	+	±
29	Skin abdomen	+	+	+
30	Skin back	+	+	+	+	+	+
31	Skin leg	+	+	+
32	LN neck	−	NE	+	+	+	+
33	LN armpit	+	+	+
34	LN armpit	±	−	+
35	LN armpit	±	−	+
36	LN armpit	+	+	+
37	LN abdomen	±	−	+
38	LN inguinal	+	−	+
39^*	LN inguinal	−	+	+	−	+	+
40	LN retroperitoneal	+	−	+
41	Gut duodenum	+	NE	+
Angioimmunoblastic lymphadenopathy with dysproteinemia
42	LN supraclavicular	+	−	+	+	−	+
Immunoblastic T-cell lymphoma
43	Skin upper arm	+	−	+

Abbreviations: LN, lymph node; ND, not done; NE, not evaluable; ALCL, anaplastic large cell lymphoma.

Recidive of an ALCL with localization in the skin and LN: + indicates a strong, ± indicates a weak, and − indicates no staining with RISH.

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