Table 6. Immune Function Data... | American Society of Hematology

Table 6.

Immune Function Data

Cell-Mediated Immunity
Immunity	Class of Test	Test	CEPRATE Arm A	Control Arm B
Cell-mediated immunity	Response to mitogens^6-152	PHA	16/16	19/20
		CON A	13/16	15/20
		PWM	7/16	10/20
	Delayed hypersensitivity skin tests	Candida	2/17	None
		Tetanus	3/17	2/17
		PPD	None	None
Immunophenotypes
n = 45 at day 100
n = 12 at 6 mo.
n = 21 at 12 mo.	NK cells (CD16⁺56⁺)		Normal no. by day 100 posttransplant	Normal no. by day 100 posttransplant
	Suppressor/cytoxic T cells (CD8⁺)

	Helper/inducer		Normal no. by 1 yr but not 100 days and 6 mo. posttransplant	Normal no. by 1 yr but not 100 days and 6 mo. posttransplant
	T cells (CD4⁺)

	B cells (CD19⁺)		Normal at 6 & 12 mo. posttransplant	Normal at 6 & 12 mo. posttransplant

	Helper/suppressor cells (CD4⁺/8⁺)		Reduced day 100, 6 & 12 mo. posttransplant	Reduced day 100, 6 & 12 mo. posttransplant

Humoral immunity
Serum Igs in mg/dL	IgM and IgA		Normal by 6 mo. posttransplant	Normal by 6 mo. posttransplant

	IgG at 6 mo. post-TX^6-150		median = 783	median = 863

	IgG at 12 mo. post-TX^6-150		median = 852	median = 1,210

Antibodies	CMV-IgG^6-151		14/17	13/15

	HSV-IgG^6-151		11/13	11/14

	VZV-IgG^6-151		All	All

Cell-Mediated Immunity
Immunity	Class of Test	Test	CEPRATE Arm A	Control Arm B
Cell-mediated immunity	Response to mitogens^6-152	PHA	16/16	19/20
		CON A	13/16	15/20
		PWM	7/16	10/20
	Delayed hypersensitivity skin tests	Candida	2/17	None
		Tetanus	3/17	2/17
		PPD	None	None
Immunophenotypes
n = 45 at day 100
n = 12 at 6 mo.
n = 21 at 12 mo.	NK cells (CD16⁺56⁺)		Normal no. by day 100 posttransplant	Normal no. by day 100 posttransplant
	Suppressor/cytoxic T cells (CD8⁺)

	Helper/inducer		Normal no. by 1 yr but not 100 days and 6 mo. posttransplant	Normal no. by 1 yr but not 100 days and 6 mo. posttransplant
	T cells (CD4⁺)

	B cells (CD19⁺)		Normal at 6 & 12 mo. posttransplant	Normal at 6 & 12 mo. posttransplant

	Helper/suppressor cells (CD4⁺/8⁺)		Reduced day 100, 6 & 12 mo. posttransplant	Reduced day 100, 6 & 12 mo. posttransplant

Humoral immunity
Serum Igs in mg/dL	IgM and IgA		Normal by 6 mo. posttransplant	Normal by 6 mo. posttransplant

	IgG at 6 mo. post-TX^6-150		median = 783	median = 863

	IgG at 12 mo. post-TX^6-150		median = 852	median = 1,210

Antibodies	CMV-IgG^6-151		14/17	13/15

	HSV-IgG^6-151		11/13	11/14

	VZV-IgG^6-151		All	All

Abbreviation: PPMV, cytomegalovirus.

Normal values = 800 to 1,800 mg/dL.

Only tested in patients who were reactive at baseline; median time for patients was at 13 months posttransplant.

Number of patients responding/number tested.