Mean Erythrocyte Half-Life
| HSA Genotype of Erythrocyte3-150 . | Phenotype of Recipient Mouse . | No. of Mice . | T1/2 (d) . | |
|---|---|---|---|---|
| . | HSA . | Rag2 . | . | . |
| + | + | + | 5 | 15.4 ± 3.6 |
| − | + | + | 5 | 3.8 ± 0.8 |
| − | − | + | 3 | 10.7 ± 1.2 |
| + | + | − | 4 | 25.0 ± 10 |
| − | + | − | 4 | 9.0 ± 2 |
| HSA Genotype of Erythrocyte3-150 . | Phenotype of Recipient Mouse . | No. of Mice . | T1/2 (d) . | |
|---|---|---|---|---|
| . | HSA . | Rag2 . | . | . |
| + | + | + | 5 | 15.4 ± 3.6 |
| − | + | + | 5 | 3.8 ± 0.8 |
| − | − | + | 3 | 10.7 ± 1.2 |
| + | + | − | 4 | 25.0 ± 10 |
| − | + | − | 4 | 9.0 ± 2 |
Fluorescently-stained normal (+) or HSA-deficient (−) erythrocytes were injected into wild-type, C57BL/6, HSA-deficient, or Rag2-deficient mice and the mean half-life was determined (see Materials and Methods).