Experimental Groups
| Exp. No. . | Sex . | Weight (kg) . | E coli Infused (CFU/kg × 1010) . | E coli Colony Count at T = 2 h (CFU/mL × 106) . | C4bBP (mg/kg) . | 7E3 F(ab′)2 (mg/kg) . | Survival (h) . |
|---|---|---|---|---|---|---|---|
| Group 1 — C4bBP alone | |||||||
| 1 | F | 4.6 | — | — | 20 | — | 168 |
| 2 | M | 5.2 | — | — | 20 | — | 168 |
| 3 | F | 8.2 | — | — | 20 | — | 168 |
| Average | — | 6.0 | — | — | 20 | — | 168 |
| SE | — | 0.4 | — | — | 0 | — | 0 |
| Group 2-Sublethal E coli alone | |||||||
| 4 | M | 6.1 | 0.93 | 3.20 | — | — | 168 |
| 5 | M | 7.1 | 0.93 | 1.04 | — | — | 168 |
| 6 | F | 14.6 | 0.84 | 7.60 | — | — | 168 |
| 7 | F | 6.4 | 1.07 | 0.28 | — | — | 168 |
| 8 | M | 5.7 | 1.13 | 0.61 | — | — | 168 |
| Average | — | 7.9 | 0.98 | 2.54 | — | — | 168 |
| SE | — | 1.67 | 0.05 | 0.28 | — | — | 0 |
| Group 3-Sublethal E coli plus C4bBP (“untreated”) | |||||||
| 9 | M | 3.9 | 1.24 | 0.48 | 20 | — | 25(s)* |
| 10 | M | 2.7 | 1.71 | 0.87 | 20 | — | 24(s) |
| 11 | F | 2.3 | 0.76 | 0.03 | 20 | — | 23(s) |
| 12 | M | 5.2 | 0.55 | 0.11 | 20 | — | 14 |
| 13 | M | 7.5 | 1.34 | 0.73 | 20 | — | 30(s) |
| Average | — | 4.32 | 1.12 | 0.44 | 20 | — | — |
| SE | — | 0.94 | 0.20 | 0.17 | 0 | — | — |
| Group 4-7E3 F(ab′)2 plus sublethal E coli plus C4bBP (“treated”) | |||||||
| 14 | F | 7.3 | 1.2 | 0.92 | 20 | 0.25 bolus | 48(s) |
| 0.25 infusion | |||||||
| 15 | F | 7.7 | 1.1 | 0.26 | 20 | 0.35 bolus | 72(s) |
| 0.35 infusion | |||||||
| 16 | M | 6.8 | 1.2 | 0.61 | 20 | 0.35 bolus | 48(s) |
| 0.35 infusion | |||||||
| 17 | F | 8.2 | 1.3 | 0.22 | 20 | 0.35 bolus | 7 days(s) |
| 0.35 infusion | |||||||
| Average | — | 7.5 | 1.20 | 0.50 | 20 | — | — |
| SE | — | 0.30 | 0.04 | 0.16 | 0 | — | — |
| Exp. No. . | Sex . | Weight (kg) . | E coli Infused (CFU/kg × 1010) . | E coli Colony Count at T = 2 h (CFU/mL × 106) . | C4bBP (mg/kg) . | 7E3 F(ab′)2 (mg/kg) . | Survival (h) . |
|---|---|---|---|---|---|---|---|
| Group 1 — C4bBP alone | |||||||
| 1 | F | 4.6 | — | — | 20 | — | 168 |
| 2 | M | 5.2 | — | — | 20 | — | 168 |
| 3 | F | 8.2 | — | — | 20 | — | 168 |
| Average | — | 6.0 | — | — | 20 | — | 168 |
| SE | — | 0.4 | — | — | 0 | — | 0 |
| Group 2-Sublethal E coli alone | |||||||
| 4 | M | 6.1 | 0.93 | 3.20 | — | — | 168 |
| 5 | M | 7.1 | 0.93 | 1.04 | — | — | 168 |
| 6 | F | 14.6 | 0.84 | 7.60 | — | — | 168 |
| 7 | F | 6.4 | 1.07 | 0.28 | — | — | 168 |
| 8 | M | 5.7 | 1.13 | 0.61 | — | — | 168 |
| Average | — | 7.9 | 0.98 | 2.54 | — | — | 168 |
| SE | — | 1.67 | 0.05 | 0.28 | — | — | 0 |
| Group 3-Sublethal E coli plus C4bBP (“untreated”) | |||||||
| 9 | M | 3.9 | 1.24 | 0.48 | 20 | — | 25(s)* |
| 10 | M | 2.7 | 1.71 | 0.87 | 20 | — | 24(s) |
| 11 | F | 2.3 | 0.76 | 0.03 | 20 | — | 23(s) |
| 12 | M | 5.2 | 0.55 | 0.11 | 20 | — | 14 |
| 13 | M | 7.5 | 1.34 | 0.73 | 20 | — | 30(s) |
| Average | — | 4.32 | 1.12 | 0.44 | 20 | — | — |
| SE | — | 0.94 | 0.20 | 0.17 | 0 | — | — |
| Group 4-7E3 F(ab′)2 plus sublethal E coli plus C4bBP (“treated”) | |||||||
| 14 | F | 7.3 | 1.2 | 0.92 | 20 | 0.25 bolus | 48(s) |
| 0.25 infusion | |||||||
| 15 | F | 7.7 | 1.1 | 0.26 | 20 | 0.35 bolus | 72(s) |
| 0.35 infusion | |||||||
| 16 | M | 6.8 | 1.2 | 0.61 | 20 | 0.35 bolus | 48(s) |
| 0.35 infusion | |||||||
| 17 | F | 8.2 | 1.3 | 0.22 | 20 | 0.35 bolus | 7 days(s) |
| 0.35 infusion | |||||||
| Average | — | 7.5 | 1.20 | 0.50 | 20 | — | — |
| SE | — | 0.30 | 0.04 | 0.16 | 0 | — | — |
(s) = Sacrificed.