Table 1 Patient characteristics .... | American Society of Hematology

Table 1

Patient characteristics

	Patients (n = 71)
Baseline
Male/female, n	30/41
Median age, y (range)	69 (59-83)
ECOG PS 0/1/2/3, n	21/44/5/1
Median CIRS (range)	6 (0-16)
CIRS-G >4, n (%)*	54 (77%)
CNS disease, n	1
Median WBC, 10⁹/L (range)	12.4 (0.8-348.3)
WBC ≥30 × 10⁹/L, n (%)	27 (38)
Karyotype	Successful (n = 64)
Ph on karyotype analysis	61 (95%)
Presence of ACAs, n (%)†	48 (79%)
Supernumerary Ph, n (%)	19 (31%)
Hyperdiploidy 47-50, n (%)	17 (28%)
Deletion 9p, n (%)	15 (25%)
Monosomy 7 or deletion 7p, n (%)	12 (20%)
Molecular biology, n
Bcr subtype (m/M/both)	54/17/0

	Patients (n = 71)
Baseline
Male/female, n	30/41
Median age, y (range)	69 (59-83)
ECOG PS 0/1/2/3, n	21/44/5/1
Median CIRS (range)	6 (0-16)
CIRS-G >4, n (%)*	54 (77%)
CNS disease, n	1
Median WBC, 10⁹/L (range)	12.4 (0.8-348.3)
WBC ≥30 × 10⁹/L, n (%)	27 (38)
Karyotype	Successful (n = 64)
Ph on karyotype analysis	61 (95%)
Presence of ACAs, n (%)†	48 (79%)
Supernumerary Ph, n (%)	19 (31%)
Hyperdiploidy 47-50, n (%)	17 (28%)
Deletion 9p, n (%)	15 (25%)
Monosomy 7 or deletion 7p, n (%)	12 (20%)
Molecular biology, n
Bcr subtype (m/M/both)	54/17/0

ACAs, additional cytogenetic abnormalities; Bcr, BCR-ABL breakpoint; PS, performance status; CIRS, cumulative illness rating scale; m, minor breakpoint; M, major breakpoint; WBC, white blood cell count.

n = 70.

†

Only ACAs present in at least 20% of Ph⁺ cases are listed; ACAs were often combined.

View Large

This Feature Is Available To Subscribers Only