Drugs reported to have a definite association with TMA
| Drug . | Individual patient data . | |||
|---|---|---|---|---|
| Immune . | Toxic . | |||
| Definite evidence . | Probable evidence . | Definite evidence . | Probable evidence . | |
| No. of patients reported . | ||||
| Bevacizumab | 0 | 0 | 3 | 1 |
| Cocaine | 0 | 0 | 1 | 0 |
| Cyclosporine | 0 | 0 | 15 | 1 |
| Docetaxel | 0 | 0 | 1 | 0 |
| Everolimus | 0 | 0 | 1 | 0 |
| Gemcitabine | 1 | 0 | 4 | 5 |
| Interferon α | 0 | 0 | 6 | 0 |
| Interferon β | 0 | 0 | 3 | 2 |
| Interferon polycarboxylate | 0 | 0 | 1 | 0 |
| Mitomycin | 0 | 0 | 3 | 3 |
| Muromonab-CD3 | 1 | 0 | 0 | 0 |
| Oxaliplatin | 1 | 1 | 0 | 0 |
| Penicillin | 1 | 0 | 0 | 0 |
| Pentostatin | 0 | 0 | 2 | 1 |
| Quetiapine | 1 | 0 | 0 | 0 |
| Quinine | 34 | 7 | 0 | 0 |
| Sirolimus | 0 | 0 | 8 | 1 |
| Sulfisoxazole | 1 | 0 | 0 | 0 |
| Sunitinib | 0 | 0 | 2 | 0 |
| Tacrolimus | 0 | 0 | 12 | 9 |
| Trielina | 1 | 0 | 0 | 0 |
| Vincristine | 0 | 0 | 1 | 0 |
| Drug . | Individual patient data . | |||
|---|---|---|---|---|
| Immune . | Toxic . | |||
| Definite evidence . | Probable evidence . | Definite evidence . | Probable evidence . | |
| No. of patients reported . | ||||
| Bevacizumab | 0 | 0 | 3 | 1 |
| Cocaine | 0 | 0 | 1 | 0 |
| Cyclosporine | 0 | 0 | 15 | 1 |
| Docetaxel | 0 | 0 | 1 | 0 |
| Everolimus | 0 | 0 | 1 | 0 |
| Gemcitabine | 1 | 0 | 4 | 5 |
| Interferon α | 0 | 0 | 6 | 0 |
| Interferon β | 0 | 0 | 3 | 2 |
| Interferon polycarboxylate | 0 | 0 | 1 | 0 |
| Mitomycin | 0 | 0 | 3 | 3 |
| Muromonab-CD3 | 1 | 0 | 0 | 0 |
| Oxaliplatin | 1 | 1 | 0 | 0 |
| Penicillin | 1 | 0 | 0 | 0 |
| Pentostatin | 0 | 0 | 2 | 1 |
| Quetiapine | 1 | 0 | 0 | 0 |
| Quinine | 34 | 7 | 0 | 0 |
| Sirolimus | 0 | 0 | 8 | 1 |
| Sulfisoxazole | 1 | 0 | 0 | 0 |
| Sunitinib | 0 | 0 | 2 | 0 |
| Tacrolimus | 0 | 0 | 12 | 9 |
| Trielina | 1 | 0 | 0 | 0 |
| Vincristine | 0 | 0 | 1 | 0 |
Citations for these reports are in supplemental Table 3. There were no group data reports describing definite evidence for a causal association with TMA. In addition to the 22 drugs with reports of definite evidence, 20 additional drugs/substances were reported with probable evidence (adalimumab, bupropion, ciprofloxacin, clopidogrel, ecstasy, estrogen/progesterone drugs, famciclovir, ibuprofen, imatinib mesylate, ketorolac tromethamine, mefloquine, metronidazole, nitrofurantoin, oxymorphone, piperacillin, simvastatin, snake (Hypnale species) venom, tamoxifen, temafloxacin, trimethoprim/sulfamethoxazole).