Table 4 Type of F8 gene mutation and... | American Society of Hematology

Table 4

Type of F8 gene mutation and inhibitor development in HADB

	Positive inhibitor		N
	%	n	N
Large deletions	49	45	109
> 1 exon	38	67	57
< 1 exon	11	21	52
Nonsense mutations	65	28	230
Light chain	52	43	122
Non-light chain	13	12	108
Small deletions/insertions	43	15	289
Outside poly-A run	37	19	191
Poly-A run	6	6	98
Missense mutations	20	8	246
Light chain	12	11	114
Non-light chain	8	6	132
Splice site mutations	3	7	46
Unknown	0	0	2
Total	180	20	922

	Positive inhibitor		N
	%	n	N
Large deletions	49	45	109
> 1 exon	38	67	57
< 1 exon	11	21	52
Nonsense mutations	65	28	230
Light chain	52	43	122
Non-light chain	13	12	108
Small deletions/insertions	43	15	289
Outside poly-A run	37	19	191
Poly-A run	6	6	98
Missense mutations	20	8	246
Light chain	12	11	114
Non-light chain	8	6	132
Splice site mutations	3	7	46
Unknown	0	0	2
Total	180	20	922

Data downloaded on October 8, 2010.