Table 1

A comparison of data from sacrificed MLL/AF4 Tg mice between the AAV8-IL24 and AAV8-EGFP groups

AAV8
#1#2#3#4#5
EGFP (n = 5)      
    Liver* + ++ ++ ++ ++ 
    Lung* ++ ++ ++ + + 
    Spleen* ++ ++ ++ ++ ++ 
    BM* + ++ + + ++ 
    PB† + + + + ++ 
IL24 (n = 5)      
    Liver* − − + + − 
    Lung* − − + − − 
    Spleen* − − + + − 
    BM* − − − − − 
    PB† − − + − − 
AAV8
#1#2#3#4#5
EGFP (n = 5)      
    Liver* + ++ ++ ++ ++ 
    Lung* ++ ++ ++ + + 
    Spleen* ++ ++ ++ ++ ++ 
    BM* + ++ + + ++ 
    PB† + + + + ++ 
IL24 (n = 5)      
    Liver* − − + + − 
    Lung* − − + − − 
    Spleen* − − + + − 
    BM* − − − − − 
    PB† − − + − − 

MLL indicates mixed-lineage leukemia; AAV8, adeno-associated virus type 8; EGFP, enhanced green fluorescent protein; and PB, peripheral blood.

*

For liver, lung, spleen, and BM, CD45R/B220+ mass/mm2: 0, −; 1-2, +; and 3-5, ++.

†

For PB, CD45R/B220+CD43+CD19+: < 2%, −; 2%-5%, +; and 5% <, ++.

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