Gene mutations in AML
| . | Class I . | Class II . | Class III? . | Other . |
|---|---|---|---|---|
| Pathways: | Signal Transduction | Differentiation | Epigenetic regulation | Tumor suppression |
| Genes | FLT3 | RUNX1 (AML1) | TET2 | WT1 |
| KIT | CBFβ | IDH1, IDH2 | TP53 | |
| NRAS, KRAS | CEBPA | DNMT3A | ||
| JAK2 | NPM1 | ASXL1 | ||
| PTPN11 | PU1 | EZH2 | ||
| MLL | ||||
| RARA |
| . | Class I . | Class II . | Class III? . | Other . |
|---|---|---|---|---|
| Pathways: | Signal Transduction | Differentiation | Epigenetic regulation | Tumor suppression |
| Genes | FLT3 | RUNX1 (AML1) | TET2 | WT1 |
| KIT | CBFβ | IDH1, IDH2 | TP53 | |
| NRAS, KRAS | CEBPA | DNMT3A | ||
| JAK2 | NPM1 | ASXL1 | ||
| PTPN11 | PU1 | EZH2 | ||
| MLL | ||||
| RARA |