Association results for 4-digit HLA alleles and BCP-ALL risk
| . | Cases, no. (%) . | Controls, no. (%) . | OR (95% CI) . | Pr (> t ) . |
|---|---|---|---|---|
| Class I | ||||
| HLA-A | ||||
| 0101 | 331 (21.6) | 1824 (20.6) | 1.06 (0.93-1.21) | 0.39 |
| 1101 | 103 (6.7) | 555 (6.3) | 1.08 (0.86-1.34) | 0.51 |
| 0201 | 391 (25.5) | 2243 (25.3) | 1.01 (0.89-1.14) | 0.91 |
| 2301 | 21 (1.4) | 119 (1.3) | 1.02 (0.64-1.62) | 0.94 |
| 2402 | 133 (8.7) | 732 (8.2) | 1.05 (0.87-1.28) | 0.60 |
| 2501 | 29 (1.9) | 182 (2.1) | 0.92 (0.62-1.36) | 0.67 |
| 2601* | 16 (1.0) | 156 (1.8) | 0.59 (0.35-0.98) | 0.04 |
| 2902* | 83 (5.4) | 370 (4.2) | 1.31 (1.03-1.67) | 0.03 |
| 0301 | 221 (14.4) | 1348 (15.2) | 0.94 (0.80-1.09) | 0.40 |
| 3101 | 61 (4.0) | 269 (3.0) | 1.32 (0.99-1.75) | 0.05 |
| 3201 | 56 (3.6) | 357 (4.0) | 0.90 (0.68-1.20) | 0.48 |
| 6801 | 45 (2.9) | 304 (3.4) | 0.85 (0.62-1.17) | 0.31 |
| HLA-B | ||||
| 1302 | 32 (2.0) | 182 (2.0) | 1.01 (0.69-1.48) | 0.95 |
| 1401 | 19 (1.2) | 114 (1.2) | 0.96 (0.59-1.56) | 0.86 |
| 1402* | 29 (1.8) | 251 (2.7) | 0.66 (0.45-0.97) | 0.03 |
| 1501 | 108 (6.8) | 616 (6.7) | 1.01 (0.82-1.25) | 0.93 |
| 1801 | 69 (4.3) | 374 (4.1) | 1.06 (0.82-1.38) | 0.64 |
| 2705 | 65 (4.1) | 419 (4.6) | 0.89 (0.68-1.16) | 0.38 |
| 3501 | 90 (5.7) | 466 (5.1) | 1.12 (0.89-1.41) | 0.35 |
| 3701 | 31 (1.9) | 130 (1.4) | 1.38 (0.93-2.05) | 0.11 |
| 3801 | 17 (1.1) | 66 (0.7) | 1.49 (0.87-2.54) | 0.15 |
| 4001 | 98 (6.2) | 551 (6.0) | 1.02 (0.82-1.28) | 0.83 |
| 4402 | 168 (10.6) | 1042 (11.4) | 0.92 (0.77-1.09) | 0.34 |
| 4403 | 95 (6.0) | 510 (5.6) | 1.08 (0.86-1.35) | 0.52 |
| 4901 | 17 (1.1) | 103 (1.1) | 0.95 (0.57-1.59) | 0.84 |
| 5101 | 57 (3.6) | 363 (4.0) | 0.90 (0.68-1.20) | 0.47 |
| 5501 | 28 (1.8) | 178 (1.9) | 0.90 (0.60-1.35) | 0.62 |
| 5701 | 73 (4.6) | 380 (4.1) | 1.11 (0.86-1.43) | 0.42 |
| 0702 | 242 (15.2) | 1380 (15.0) | 1.01 (0.87-1.17) | 0.89 |
| 0801 | 234 (14.7) | 1358 (14.8) | 0.99 (0.85-1.15) | 0.89 |
| HLA-C | ||||
| 0102 | 46 (2.9) | 346 (3.8) | 0.77 (0.56-1.05) | 0.10 |
| 1203 | 52 (3.3) | 274 (3.0) | 1.11 (0.82-1.50) | 0.51 |
| 1502 | 21 (1.3) | 146 (1.6) | 0.83 (0.53-1.32) | 0.44 |
| 1601 | 78 (5.0) | 389 (4.3) | 1.18 (0.92-1.51) | 0.20 |
| 0202* | 74 (4.7) | 333 (3.6) | 1.31 (1.01-1.69) | 0.04 |
| 0303 | 71 (4.5) | 525 (5.7) | 0.78 (0.60-1.00) | 0.05 |
| 0304 | 142 (9.0) | 761 (8.3) | 1.09 (0.91-1.32) | 0.35 |
| 0401 | 138 (8.8) | 768 (8.4) | 1.05 (0.87-1.27) | 0.62 |
| 0501 | 156 (9.9) | 997 (10.9) | 0.90 (0.75-1.08) | 0.25 |
| 0602 | 169 (10.8) | 874 (9.6) | 1.14 (0.96-1.36) | 0.14 |
| 0701 | 270 (17.2) | 1528 (16.7) | 1.03 (0.90-1.19) | 0.65 |
| 0702 | 256 (16.3) | 1501 (16.4) | 0.99 (0.86-1.15) | 0.90 |
| 0704 | 26 (1.7) | 154 (1.7) | 0.98 (0.65-1.49) | 0.93 |
| 0802* | 41 (2.6) | 361 (3.9) | 0.65 (0.47-0.90) | 0.01 |
| Class II | ||||
| HLA-DQA | ||||
| 0101 | 222 (14.2) | 1307 (14.7) | 0.96 (0.82-1.12) | 0.60 |
| 0102 | 287 (18.4) | 1560 (17.6) | 1.06 (0.92-1.21) | 0.45 |
| 0103 | 68 (4.4) | 458 (5.2) | 0.84 (0.64-1.09) | 0.18 |
| 0201 | 259 (16.6) | 1423 (16.0) | 1.04 (0.90-1.20) | 0.59 |
| 0301 | 313 (20.1) | 1742 (19.6) | 1.03 (0.90-1.17) | 0.70 |
| 0401 | 25 (1.6) | 192 (2.2) | 0.74 (0.48-1.12) | 0.15 |
| 0501 | 387 (24.8) | 2189 (24.7) | 1.01 (0.89-1.14) | 0.92 |
| Class II | ||||
| HLA-DQB | ||||
| 0201* | 189 (12.4) | 1322 (14.4) | 0.84 (0.72-0.99) | 0.04 |
| 0202 | 124 (8.2) | 871 (9.5) | 0.85 (0.70-1.03) | 0.10 |
| 0301 | 280 (18.4) | 1721 (18.7) | 0.98 (0.85-1.13) | 0.77 |
| 0302* | 192 (12.6) | 981 (10.7) | 1.21 (1.03-1.43) | 0.02 |
| 0303* | 104 (6.8) | 506 (5.5) | 1.26 (1.01-1.57) | 0.04 |
| 0402 | 26 (1.7) | 197 (2.1) | 0.79 (0.53-1.20) | 0.27 |
| 0501 | 206 (13.6) | 1093 (11.9) | 1.16 (0.99-1.36) | 0.07 |
| 0503 | 27 (1.8) | 231 (2.5) | 0.70 (0.47-1.05) | 0.08 |
| 0602 | 227 (14.9) | 1265 (13.7) | 1.10 (0.94-1.28) | 0.22 |
| 0603 | 77 (5.1) | 505 (5.5) | 0.92 (0.72-1.17) | 0.49 |
| 0604 | 37 (2.4) | 291 (3.2) | 0.76 (0.54-1.08) | 0.13 |
| HLA-DRB | ||||
| 0101 | 134 (9.5) | 689 (8.2) | 1.17 (0.96-1.42) | 0.11 |
| 0103 | 29 (2.1) | 149 (1.8) | 1.16 (0.78-1.73) | 0.47 |
| 1101 | 44 (3.1) | 240 (2.8) | 1.09 (0.79-1.51) | 0.60 |
| 1201 | 25 (1.8) | 144 (1.7) | 1.03 (0.67-1.58) | 0.89 |
| 1301 | 77 (5.4) | 489 (5.8) | 0.93 (0.73-1.19) | 0.57 |
| 1302* | 49 (3.5) | 410 (4.9) | 0.70 (0.52-0.95) | 0.02 |
| 1303 | 16 (1.1) | 85 (1.0) | 1.12 (0.65-1.91) | 0.68 |
| 1401 | 30 (2.1) | 217 (2.6) | 0.82 (0.56-1.20) | 0.30 |
| 1501 | 225 (15.9) | 1249 (14.8) | 1.08 (0.93-1.26) | 0.31 |
| 0301 | 238 (16.8) | 1386 (16.4) | 1.02 (0.88-1.19) | 0.76 |
| 0401 | 145 (10.3) | 884 (10.5) | 0.97 (0.81-1.17) | 0.76 |
| 0404 | 57 (4.0) | 349 (4.1) | 0.97 (0.73-1.29) | 0.83 |
| 0701 | 244 (17.3) | 1375 (16.3) | 1.06 (0.92-1.24) | 0.41 |
| 0801 | 23 (1.6) | 180 (2.1) | 0.75 (0.49-1.17) | 0.21 |
| 0901 | 21 (1.5) | 119 (1.4) | 1.05 (0.66-1.67) | 0.84 |
| . | Cases, no. (%) . | Controls, no. (%) . | OR (95% CI) . | Pr (> t ) . |
|---|---|---|---|---|
| Class I | ||||
| HLA-A | ||||
| 0101 | 331 (21.6) | 1824 (20.6) | 1.06 (0.93-1.21) | 0.39 |
| 1101 | 103 (6.7) | 555 (6.3) | 1.08 (0.86-1.34) | 0.51 |
| 0201 | 391 (25.5) | 2243 (25.3) | 1.01 (0.89-1.14) | 0.91 |
| 2301 | 21 (1.4) | 119 (1.3) | 1.02 (0.64-1.62) | 0.94 |
| 2402 | 133 (8.7) | 732 (8.2) | 1.05 (0.87-1.28) | 0.60 |
| 2501 | 29 (1.9) | 182 (2.1) | 0.92 (0.62-1.36) | 0.67 |
| 2601* | 16 (1.0) | 156 (1.8) | 0.59 (0.35-0.98) | 0.04 |
| 2902* | 83 (5.4) | 370 (4.2) | 1.31 (1.03-1.67) | 0.03 |
| 0301 | 221 (14.4) | 1348 (15.2) | 0.94 (0.80-1.09) | 0.40 |
| 3101 | 61 (4.0) | 269 (3.0) | 1.32 (0.99-1.75) | 0.05 |
| 3201 | 56 (3.6) | 357 (4.0) | 0.90 (0.68-1.20) | 0.48 |
| 6801 | 45 (2.9) | 304 (3.4) | 0.85 (0.62-1.17) | 0.31 |
| HLA-B | ||||
| 1302 | 32 (2.0) | 182 (2.0) | 1.01 (0.69-1.48) | 0.95 |
| 1401 | 19 (1.2) | 114 (1.2) | 0.96 (0.59-1.56) | 0.86 |
| 1402* | 29 (1.8) | 251 (2.7) | 0.66 (0.45-0.97) | 0.03 |
| 1501 | 108 (6.8) | 616 (6.7) | 1.01 (0.82-1.25) | 0.93 |
| 1801 | 69 (4.3) | 374 (4.1) | 1.06 (0.82-1.38) | 0.64 |
| 2705 | 65 (4.1) | 419 (4.6) | 0.89 (0.68-1.16) | 0.38 |
| 3501 | 90 (5.7) | 466 (5.1) | 1.12 (0.89-1.41) | 0.35 |
| 3701 | 31 (1.9) | 130 (1.4) | 1.38 (0.93-2.05) | 0.11 |
| 3801 | 17 (1.1) | 66 (0.7) | 1.49 (0.87-2.54) | 0.15 |
| 4001 | 98 (6.2) | 551 (6.0) | 1.02 (0.82-1.28) | 0.83 |
| 4402 | 168 (10.6) | 1042 (11.4) | 0.92 (0.77-1.09) | 0.34 |
| 4403 | 95 (6.0) | 510 (5.6) | 1.08 (0.86-1.35) | 0.52 |
| 4901 | 17 (1.1) | 103 (1.1) | 0.95 (0.57-1.59) | 0.84 |
| 5101 | 57 (3.6) | 363 (4.0) | 0.90 (0.68-1.20) | 0.47 |
| 5501 | 28 (1.8) | 178 (1.9) | 0.90 (0.60-1.35) | 0.62 |
| 5701 | 73 (4.6) | 380 (4.1) | 1.11 (0.86-1.43) | 0.42 |
| 0702 | 242 (15.2) | 1380 (15.0) | 1.01 (0.87-1.17) | 0.89 |
| 0801 | 234 (14.7) | 1358 (14.8) | 0.99 (0.85-1.15) | 0.89 |
| HLA-C | ||||
| 0102 | 46 (2.9) | 346 (3.8) | 0.77 (0.56-1.05) | 0.10 |
| 1203 | 52 (3.3) | 274 (3.0) | 1.11 (0.82-1.50) | 0.51 |
| 1502 | 21 (1.3) | 146 (1.6) | 0.83 (0.53-1.32) | 0.44 |
| 1601 | 78 (5.0) | 389 (4.3) | 1.18 (0.92-1.51) | 0.20 |
| 0202* | 74 (4.7) | 333 (3.6) | 1.31 (1.01-1.69) | 0.04 |
| 0303 | 71 (4.5) | 525 (5.7) | 0.78 (0.60-1.00) | 0.05 |
| 0304 | 142 (9.0) | 761 (8.3) | 1.09 (0.91-1.32) | 0.35 |
| 0401 | 138 (8.8) | 768 (8.4) | 1.05 (0.87-1.27) | 0.62 |
| 0501 | 156 (9.9) | 997 (10.9) | 0.90 (0.75-1.08) | 0.25 |
| 0602 | 169 (10.8) | 874 (9.6) | 1.14 (0.96-1.36) | 0.14 |
| 0701 | 270 (17.2) | 1528 (16.7) | 1.03 (0.90-1.19) | 0.65 |
| 0702 | 256 (16.3) | 1501 (16.4) | 0.99 (0.86-1.15) | 0.90 |
| 0704 | 26 (1.7) | 154 (1.7) | 0.98 (0.65-1.49) | 0.93 |
| 0802* | 41 (2.6) | 361 (3.9) | 0.65 (0.47-0.90) | 0.01 |
| Class II | ||||
| HLA-DQA | ||||
| 0101 | 222 (14.2) | 1307 (14.7) | 0.96 (0.82-1.12) | 0.60 |
| 0102 | 287 (18.4) | 1560 (17.6) | 1.06 (0.92-1.21) | 0.45 |
| 0103 | 68 (4.4) | 458 (5.2) | 0.84 (0.64-1.09) | 0.18 |
| 0201 | 259 (16.6) | 1423 (16.0) | 1.04 (0.90-1.20) | 0.59 |
| 0301 | 313 (20.1) | 1742 (19.6) | 1.03 (0.90-1.17) | 0.70 |
| 0401 | 25 (1.6) | 192 (2.2) | 0.74 (0.48-1.12) | 0.15 |
| 0501 | 387 (24.8) | 2189 (24.7) | 1.01 (0.89-1.14) | 0.92 |
| Class II | ||||
| HLA-DQB | ||||
| 0201* | 189 (12.4) | 1322 (14.4) | 0.84 (0.72-0.99) | 0.04 |
| 0202 | 124 (8.2) | 871 (9.5) | 0.85 (0.70-1.03) | 0.10 |
| 0301 | 280 (18.4) | 1721 (18.7) | 0.98 (0.85-1.13) | 0.77 |
| 0302* | 192 (12.6) | 981 (10.7) | 1.21 (1.03-1.43) | 0.02 |
| 0303* | 104 (6.8) | 506 (5.5) | 1.26 (1.01-1.57) | 0.04 |
| 0402 | 26 (1.7) | 197 (2.1) | 0.79 (0.53-1.20) | 0.27 |
| 0501 | 206 (13.6) | 1093 (11.9) | 1.16 (0.99-1.36) | 0.07 |
| 0503 | 27 (1.8) | 231 (2.5) | 0.70 (0.47-1.05) | 0.08 |
| 0602 | 227 (14.9) | 1265 (13.7) | 1.10 (0.94-1.28) | 0.22 |
| 0603 | 77 (5.1) | 505 (5.5) | 0.92 (0.72-1.17) | 0.49 |
| 0604 | 37 (2.4) | 291 (3.2) | 0.76 (0.54-1.08) | 0.13 |
| HLA-DRB | ||||
| 0101 | 134 (9.5) | 689 (8.2) | 1.17 (0.96-1.42) | 0.11 |
| 0103 | 29 (2.1) | 149 (1.8) | 1.16 (0.78-1.73) | 0.47 |
| 1101 | 44 (3.1) | 240 (2.8) | 1.09 (0.79-1.51) | 0.60 |
| 1201 | 25 (1.8) | 144 (1.7) | 1.03 (0.67-1.58) | 0.89 |
| 1301 | 77 (5.4) | 489 (5.8) | 0.93 (0.73-1.19) | 0.57 |
| 1302* | 49 (3.5) | 410 (4.9) | 0.70 (0.52-0.95) | 0.02 |
| 1303 | 16 (1.1) | 85 (1.0) | 1.12 (0.65-1.91) | 0.68 |
| 1401 | 30 (2.1) | 217 (2.6) | 0.82 (0.56-1.20) | 0.30 |
| 1501 | 225 (15.9) | 1249 (14.8) | 1.08 (0.93-1.26) | 0.31 |
| 0301 | 238 (16.8) | 1386 (16.4) | 1.02 (0.88-1.19) | 0.76 |
| 0401 | 145 (10.3) | 884 (10.5) | 0.97 (0.81-1.17) | 0.76 |
| 0404 | 57 (4.0) | 349 (4.1) | 0.97 (0.73-1.29) | 0.83 |
| 0701 | 244 (17.3) | 1375 (16.3) | 1.06 (0.92-1.24) | 0.41 |
| 0801 | 23 (1.6) | 180 (2.1) | 0.75 (0.49-1.17) | 0.21 |
| 0901 | 21 (1.5) | 119 (1.4) | 1.05 (0.66-1.67) | 0.84 |
Only alleles present in > 1% of cases are shown.
Alleles showing an association with ALL risk at P < .05.