Table 3 Currently available intravenous... | American Society of Hematology

Table 3

Currently available intravenous iron preparations

Trade name	DexFerrum	INFeD	Ferrlecit	Venofer	Ferumoxytol	Injectafer*
Manufacturer	American Regent, Inc.	Watson Pharmaceuticals, Inc.	Watson Pharmaceuticals, Inc.	American Regent, Inc.	AMAG Pharmaceuticals	American Regent, Inc.
Carbohydrate	High-molecular-weight dextran	Low-molecular-weight dextran	Gluconate	Sucrose	Polyglucose sorbitol carboxymethylether	Carboxymaltose
Molecular weight measured by manufacturer (Da)	265 000	165 000	289 000-440 000	34 000-60 000	750 000	150 000
Total dose or > 500-mg infusion	Yes	Yes	No	No	Yes	Yes
Premedication	TDI only	TDI only	No	No	No	No
Test does required	Yes	Yes	No	No	No	No
Iron concentration (mg/mL)	50	50	12.5	20	30	50
Vial volume (mL)	1-2	2	5	5	17	2 or 10
Black box warning	Yes	Yes	No	No	No	No
Preservative	None	None	Benzyl alcohol	None	None	None

Trade name	DexFerrum	INFeD	Ferrlecit	Venofer	Ferumoxytol	Injectafer*
Manufacturer	American Regent, Inc.	Watson Pharmaceuticals, Inc.	Watson Pharmaceuticals, Inc.	American Regent, Inc.	AMAG Pharmaceuticals	American Regent, Inc.
Carbohydrate	High-molecular-weight dextran	Low-molecular-weight dextran	Gluconate	Sucrose	Polyglucose sorbitol carboxymethylether	Carboxymaltose
Molecular weight measured by manufacturer (Da)	265 000	165 000	289 000-440 000	34 000-60 000	750 000	150 000
Total dose or > 500-mg infusion	Yes	Yes	No	No	Yes	Yes
Premedication	TDI only	TDI only	No	No	No	No
Test does required	Yes	Yes	No	No	No	No
Iron concentration (mg/mL)	50	50	12.5	20	30	50
Vial volume (mL)	1-2	2	5	5	17	2 or 10
Black box warning	Yes	Yes	No	No	No	No
Preservative	None	None	Benzyl alcohol	None	None	None

Ferric gluconate and iron sucrose are also referred to as iron salts.

TDI indicates total dose infusion.

Not approved in the United States.

Updated from M. Auerbach.⁵⁶