Cleavage sites of leukocyte proteases in the VWF-A2 domain
| Protease . | FRETS-VWF73 fragment size, Daltons . | VWF fragment N-terminal sequence* . | VWF cleavage site . |
|---|---|---|---|
| Elastase | 6790 | TGNPASDE | V1607-T1608 |
| PR3 | 6793 | TGNPASDE | V1607-T1608 |
| Cathepsin G | 7036 | MVTGNPAS | T1605-M1606 |
| MMP9 | 6898 | Not determined | M1606-V1607 |
| Protease . | FRETS-VWF73 fragment size, Daltons . | VWF fragment N-terminal sequence* . | VWF cleavage site . |
|---|---|---|---|
| Elastase | 6790 | TGNPASDE | V1607-T1608 |
| PR3 | 6793 | TGNPASDE | V1607-T1608 |
| Cathepsin G | 7036 | MVTGNPAS | T1605-M1606 |
| MMP9 | 6898 | Not determined | M1606-V1607 |
VWF indicates von Willebrand factor.
Sequence was derived from a 175-kDa cleavage fragment of multimeric VWF.