Small molecule inhibitors involved in the suppression of translation
| Drug . | Binding Site . | Mechanism of action . | Reference(s) . |
|---|---|---|---|
| Ribavirin | 5′ methyl-7-GTP cap | Competitive inhibitor of eIF4E binding to capped mRNA | 29,30 |
| 4EGI-1 | eIF4G | Competitive inhibitor of eIF4E binding to eIF4G | 31,32 |
| GnRH-4EBP fusion peptide | eIF4E | Peptidomimetic inhibitor of eIF4E binding to eIF4G | 35 |
| Rapamycin, analogs and derivatives | FKBP-rapamycin-binding (FRB) domain of mTOR | Inhibits recruitment of FKBP12 protein to mTOR | Reviewed in 45 |
| Torin1 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 34 |
| PP242 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
| PP30 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
| CGP57380 | MNK kinase domain | Inhibition of ATP binding to kinase domain | 113,,–116 |
| Drug . | Binding Site . | Mechanism of action . | Reference(s) . |
|---|---|---|---|
| Ribavirin | 5′ methyl-7-GTP cap | Competitive inhibitor of eIF4E binding to capped mRNA | 29,30 |
| 4EGI-1 | eIF4G | Competitive inhibitor of eIF4E binding to eIF4G | 31,32 |
| GnRH-4EBP fusion peptide | eIF4E | Peptidomimetic inhibitor of eIF4E binding to eIF4G | 35 |
| Rapamycin, analogs and derivatives | FKBP-rapamycin-binding (FRB) domain of mTOR | Inhibits recruitment of FKBP12 protein to mTOR | Reviewed in 45 |
| Torin1 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 34 |
| PP242 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
| PP30 | mTOR kinase domain | Inhibition of ATP binding to kinase domain | 62 |
| CGP57380 | MNK kinase domain | Inhibition of ATP binding to kinase domain | 113,,–116 |