Table 3
Distribution of MolR according to CBA and I-FISH data
| Molecular response | |||||
|---|---|---|---|---|---|
| Major MolR, n (%) | P | Median BCR-ABL transcripts level* | P | ||
| Cytogenetic response by I-FISH and by CBA | No Ph+ metaphases and < 1% BCR-ABL+ nuclei (n = 425) | 281 (66.1) | 0.035 | ||
| .004 | .06 | ||||
| No Ph+ metaphases but ≥ 1% BCR-ABL+ nuclei (n = 87) | 43 (49.4) | 0.079 | |||
| Cytogenetic response by I-FISH | No BCR-ABL+ nuclei (n = 396) | 263 (66.4) | 0.031 | ||
 | .68 | | .43 | ||
| 0.1%-0.9% BCR-ABL+ nuclei (n = 29) | 21 (72.4) | 0.043 | |||
 | < .001 | | < .001 | ||
| 1%-5% BCR-ABL+ nuclei (n = 95) | 49 (51.6) | 0.082 | |||
| Molecular response | |||||
|---|---|---|---|---|---|
| Major MolR, n (%) | P | Median BCR-ABL transcripts level* | P | ||
| Cytogenetic response by I-FISH and by CBA | No Ph+ metaphases and < 1% BCR-ABL+ nuclei (n = 425) | 281 (66.1) | 0.035 | ||
| .004 | .06 | ||||
| No Ph+ metaphases but ≥ 1% BCR-ABL+ nuclei (n = 87) | 43 (49.4) | 0.079 | |||
| Cytogenetic response by I-FISH | No BCR-ABL+ nuclei (n = 396) | 263 (66.4) | 0.031 | ||
| | .68 | | .43 | ||
| 0.1%-0.9% BCR-ABL+ nuclei (n = 29) | 21 (72.4) | 0.043 | |||
| | < .001 | | < .001 | ||
| 1%-5% BCR-ABL+ nuclei (n = 95) | 49 (51.6) | 0.082 | |||
CBA indicates chromosome banding analysis; I-FISH, interphase fluorescence in situ hybridization; and MolR, molecular response.
*
BCR-ABL/ABL% on the international scale.