Table 2 Fibrin network density in clots... | American Society of Hematology

Table 2

Fibrin network density in clots formed by in situ thrombin generation on fibroblasts, SMCs, HUVECs, and TNFα-stimulated HUVECs

	Fibrin network density		P, 0-10 μm versus 40-50 μm
	0-10 μm	40-50 μm	P, 0-10 μm versus 40-50 μm
Fibroblasts
+ Control peptide	0.796 ± 0.035	0.515 ± 0.045	.001
+ GRGDSP	0.835 ± 0.012	0.527 ± 0.054	.016
P, ± GRGDSP	NS	NS
SMCs
+ Control peptide	0.683 ± 0.034	0.455 ± 0.062	.001
+ GRGDSP	0.666 ± 0.058	0.446 ± 0.001	.003
P, ± GRGDSP	NS	NS
HUVECs
+ Control peptide	0.546 ± 0.053	0.306 ± 0.050	.001
+ GRGDSP	0.579 ± 0.114	0.364 ± 0.020	.03
P, ± GRGDSP	NS	NS
HUVECs + TNFα
+ Control peptide	0.723 ± 0.037	0.468 ± 0.011	.001
+ GRGDSP	0.730 ± 0.005	0.475 ± 0.059	.026
P, ± GRGDSP	NS	NS

	Fibrin network density		P, 0-10 μm versus 40-50 μm
	0-10 μm	40-50 μm	P, 0-10 μm versus 40-50 μm
Fibroblasts
+ Control peptide	0.796 ± 0.035	0.515 ± 0.045	.001
+ GRGDSP	0.835 ± 0.012	0.527 ± 0.054	.016
P, ± GRGDSP	NS	NS
SMCs
+ Control peptide	0.683 ± 0.034	0.455 ± 0.062	.001
+ GRGDSP	0.666 ± 0.058	0.446 ± 0.001	.003
P, ± GRGDSP	NS	NS
HUVECs
+ Control peptide	0.546 ± 0.053	0.306 ± 0.050	.001
+ GRGDSP	0.579 ± 0.114	0.364 ± 0.020	.03
P, ± GRGDSP	NS	NS
HUVECs + TNFα
+ Control peptide	0.723 ± 0.037	0.468 ± 0.011	.001
+ GRGDSP	0.730 ± 0.005	0.475 ± 0.059	.026
P, ± GRGDSP	NS	NS

SMC indicates smooth muscle cell; HUVEC, human umbilical vein endothelial cell; TNFα, tumor necrosis factor-α; and NS, not significantly different with control (GRDESP) or β3-blocking (GRDGSP) peptide.

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