Table 5

Multivariate analysis of treatment failure (relapse or death) among patients 16 years of age and older who underwent URD transplants for Philadelphia-negative ALL in CR1

VariableEvent/no. evaluableRelative risk of relapse or death (95% CI)P
WBC at diagnosis    
    100 × 109/L or less* 74/113 1.00§ Poverall‖ = .004 
    More than 100 × 109/L 26/38 1.80 (1.13-2.87) P12 = .014 
    Unknown 11/14 2.56 (1.32-4.95) P13 = .005 
Time from diagnosis to CR1    
    8 wk or less† 53/97 1.00§  
    More than 8 wk 47/68 1.77 (1.18-2.65) .006 
Donor-recipient CMV status    
    D−/R− 30/54 1.00§  
    D+ or R+ 70/111 1.61 (1.02v2.54) .040 
Donor-recipient HLA match    
    Well or partially matched‡ 77/136 1.00§  
    Mismatched 23/29 2.09 (1.30-3.37) .003 
T-cell depletion    
    No 87/149 1.00§  
    Yes 13/16 2.50 (1.37-4.58) .003 
VariableEvent/no. evaluableRelative risk of relapse or death (95% CI)P
WBC at diagnosis    
    100 × 109/L or less* 74/113 1.00§ Poverall‖ = .004 
    More than 100 × 109/L 26/38 1.80 (1.13-2.87) P12 = .014 
    Unknown 11/14 2.56 (1.32-4.95) P13 = .005 
Time from diagnosis to CR1    
    8 wk or less† 53/97 1.00§  
    More than 8 wk 47/68 1.77 (1.18-2.65) .006 
Donor-recipient CMV status    
    D−/R− 30/54 1.00§  
    D+ or R+ 70/111 1.61 (1.02v2.54) .040 
Donor-recipient HLA match    
    Well or partially matched‡ 77/136 1.00§  
    Mismatched 23/29 2.09 (1.30-3.37) .003 
T-cell depletion    
    No 87/149 1.00§  
    Yes 13/16 2.50 (1.37-4.58) .003 
*

Thirty to 100 × 109/L versus less than 30 × 109/L: RR = 0.85 (0.49-1.49); P = .58.

†

Less than four weeks versus 4 to 8 weeks: RR = 0.76 (0.43-1.34); P = .34.

‡

Partially matched versus well matched: RR = 0.98 (0.61-1.57); P = .94.

§

Reference group.

‖

Two degrees of freedom.

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