Table 3 Multivariate analysis of... | American Society of Hematology

Table 3

Multivariate analysis of treatment-related mortality and relapse among patients 16 years of age and older who underwent URD transplants for Philadelphia-negative ALL in first complete remission

Variable	Event/no. evaluable	Relative risk (95% CI)	P
Treatment-related mortality*
Donor-recipient HLA match
Well or partially matched†	52/136	1.00§
Mismatched	16/29	1.83 (1.04-3.22)	.037
T-cell depletion
No	56/149	1.00§
Yes	12/16	2.67 (1.42-4.99)	.002
Relapse
WBC at diagnosis
100 × 10⁹/L or less‡	22/113	1.00§	P_overall‖ = .001
More than 100 × 10⁹/L	10/38	2.96 (1.31-6.69)	P₁₂ = .009
Unknown	5/14	5.40 (1.92-15.17)	P₁₃ = .001
Time from diagnosis to CR11
8 weeks or less	15/97	1.00§
More than 8 weeks	17/68	2.22 (1.09-4.53)	.028
Donor-recipient CMV status
D⁻/R⁻	30/54	1.00§
D⁺ or R⁺	70/111	2.34 (0.99-5.54)	.05
Donor-recipient HLA match
Well or partially matched	25/136	1.00§
Mismatched	7/29	2.53 (1.05-6.08)	.038

Variable	Event/no. evaluable	Relative risk (95% CI)	P
Treatment-related mortality*
Donor-recipient HLA match
Well or partially matched†	52/136	1.00§
Mismatched	16/29	1.83 (1.04-3.22)	.037
T-cell depletion
No	56/149	1.00§
Yes	12/16	2.67 (1.42-4.99)	.002
Relapse
WBC at diagnosis
100 × 10⁹/L or less‡	22/113	1.00§	P_overall‖ = .001
More than 100 × 10⁹/L	10/38	2.96 (1.31-6.69)	P₁₂ = .009
Unknown	5/14	5.40 (1.92-15.17)	P₁₃ = .001
Time from diagnosis to CR11
8 weeks or less	15/97	1.00§
More than 8 weeks	17/68	2.22 (1.09-4.53)	.028
Donor-recipient CMV status
D⁻/R⁻	30/54	1.00§
D⁺ or R⁺	70/111	2.34 (0.99-5.54)	.05
Donor-recipient HLA match
Well or partially matched	25/136	1.00§
Mismatched	7/29	2.53 (1.05-6.08)	.038

D⁺ or R⁺ CMV match vs D-/R-: RR = 1.36 (0.79-2.33); P = .27.

†

Partially matched vs well matched: RR = 1.02 (0.59-1.77); P = .94.

‡

Thirty to 100 × 10⁹/L vs less than 30 × 10⁹/L: RR = 1.37 (0.52-3.61); P = .52.

Reference group.

‖

Two degrees of freedom.

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