Number of patients by demographic, prognostic feature, and genotype categories who were in best-versus-worst MRD groups
| . | Best* . | Worst . |
|---|---|---|
| Sex | ||
| Male | 153 | 153 |
| Female | 124 | 99 |
| Race | ||
| White | 173 | 160 |
| Hispanic | 54 | 56 |
| African American | 20 | 9 |
| Other | 30 | 27 |
| NCI | ||
| Standard risk | 211 | 136 |
| High risk | 66 | 116 |
| Hyperdiploidy | ||
| No | 228 | 183 |
| Yes | 47 | 69 |
| Missing | 2 | 0 |
| MLL rearrangement | ||
| No | 275 | 241 |
| Yes | 2 | 11 |
| Missing | 0 | 0 |
| TEL-AML1 | ||
| No | 167 | 223 |
| Yes | 109 | 27 |
| Missing | 1 | 2 |
| Trisomy 4 and 10 | ||
| No | 230 | 193 |
| Yes | 47 | 58 |
| Missing | 0 | 1 |
| ADRB21 -468 C>G, rs11168070 | ||
| CC | 118 | 113 |
| CG and GG | 134 | 127 |
| Missing | 25 | 12 |
| CCR5 +246 A>G, rs1799987 | ||
| AA | 67 | 73 |
| AG and GG | 189 | 145 |
| Missing | 21 | 34 |
| CONNEXIN 1019 C>T, rs1764391 | ||
| CC | 120 | 108 |
| CT and TT | 134 | 114 |
| Missing | 23 | 30 |
| GSTP1 313 A>G, rs947894 | ||
| AA and AG | 221 | 193 |
| GG | 33 | 27 |
| Missing | 23 | 32 |
| MBP codon 54, rs1800450 | ||
| AA | 2 | 4 |
| AG and GG | 258 | 215 |
| Missing | 17 | 33 |
| MDR1 exon 21 2677, rs 2032581 | ||
| GG | 96 | 85 |
| Others | 158 | 150 |
| Missing | 23 | 17 |
| MDR1 exon 26 3435 C>T, rs1045642 | ||
| CC | 76 | 57 |
| CT and TT | 189 | 190 |
| Missing | 12 | 5 |
| MTHFR 677 C>T, rs1801133 | ||
| CC | 114 | 100 |
| CT and TT | 157 | 145 |
| Missing | 6 | 7 |
| MTHFR 1298 A>C, rs1801131 | ||
| AA | 129 | 125 |
| AC and CC | 142 | 120 |
| Missing | 6 | 7 |
| NQO1 609 C>T, rs 1800566 | ||
| CC | 154 | 112 |
| CT and TT | 102 | 112 |
| Missing | 21 | 28 |
| CYBA P22rs4673 | ||
| CC | 121 | 92 |
| CT and TT | 138 | 124 |
| Missing | 18 | 36 |
| RFC 80 A>G, rs1051266 | ||
| AA and AG | 182 | 157 |
| GG | 73 | 79 |
| Missing | 22 | 16 |
| TPMT 460 G>A, rs 1142345 | ||
| AA and AG | 16 | 16 |
| GG | 246 | 208 |
| Missing | 15 | 28 |
| TYMS - 827 promoter enhancer repeat | ||
| 3AND3 | 79 | 77 |
| Others | 176 | 161 |
| Missing | 22 | 14 |
| VDR Fok1 Start site C>T, rs1073581 | ||
| CC | 105 | 92 |
| CC and CT | 156 | 133 |
| Missing | 16 | 27 |
| VDR intron 8 G>A, rs1544410 | ||
| AA and AG | 71 | 61 |
| GG | 51 | 48 |
| Missing | 155 | 143 |
| . | Best* . | Worst . |
|---|---|---|
| Sex | ||
| Male | 153 | 153 |
| Female | 124 | 99 |
| Race | ||
| White | 173 | 160 |
| Hispanic | 54 | 56 |
| African American | 20 | 9 |
| Other | 30 | 27 |
| NCI | ||
| Standard risk | 211 | 136 |
| High risk | 66 | 116 |
| Hyperdiploidy | ||
| No | 228 | 183 |
| Yes | 47 | 69 |
| Missing | 2 | 0 |
| MLL rearrangement | ||
| No | 275 | 241 |
| Yes | 2 | 11 |
| Missing | 0 | 0 |
| TEL-AML1 | ||
| No | 167 | 223 |
| Yes | 109 | 27 |
| Missing | 1 | 2 |
| Trisomy 4 and 10 | ||
| No | 230 | 193 |
| Yes | 47 | 58 |
| Missing | 0 | 1 |
| ADRB21 -468 C>G, rs11168070 | ||
| CC | 118 | 113 |
| CG and GG | 134 | 127 |
| Missing | 25 | 12 |
| CCR5 +246 A>G, rs1799987 | ||
| AA | 67 | 73 |
| AG and GG | 189 | 145 |
| Missing | 21 | 34 |
| CONNEXIN 1019 C>T, rs1764391 | ||
| CC | 120 | 108 |
| CT and TT | 134 | 114 |
| Missing | 23 | 30 |
| GSTP1 313 A>G, rs947894 | ||
| AA and AG | 221 | 193 |
| GG | 33 | 27 |
| Missing | 23 | 32 |
| MBP codon 54, rs1800450 | ||
| AA | 2 | 4 |
| AG and GG | 258 | 215 |
| Missing | 17 | 33 |
| MDR1 exon 21 2677, rs 2032581 | ||
| GG | 96 | 85 |
| Others | 158 | 150 |
| Missing | 23 | 17 |
| MDR1 exon 26 3435 C>T, rs1045642 | ||
| CC | 76 | 57 |
| CT and TT | 189 | 190 |
| Missing | 12 | 5 |
| MTHFR 677 C>T, rs1801133 | ||
| CC | 114 | 100 |
| CT and TT | 157 | 145 |
| Missing | 6 | 7 |
| MTHFR 1298 A>C, rs1801131 | ||
| AA | 129 | 125 |
| AC and CC | 142 | 120 |
| Missing | 6 | 7 |
| NQO1 609 C>T, rs 1800566 | ||
| CC | 154 | 112 |
| CT and TT | 102 | 112 |
| Missing | 21 | 28 |
| CYBA P22rs4673 | ||
| CC | 121 | 92 |
| CT and TT | 138 | 124 |
| Missing | 18 | 36 |
| RFC 80 A>G, rs1051266 | ||
| AA and AG | 182 | 157 |
| GG | 73 | 79 |
| Missing | 22 | 16 |
| TPMT 460 G>A, rs 1142345 | ||
| AA and AG | 16 | 16 |
| GG | 246 | 208 |
| Missing | 15 | 28 |
| TYMS - 827 promoter enhancer repeat | ||
| 3AND3 | 79 | 77 |
| Others | 176 | 161 |
| Missing | 22 | 14 |
| VDR Fok1 Start site C>T, rs1073581 | ||
| CC | 105 | 92 |
| CC and CT | 156 | 133 |
| Missing | 16 | 27 |
| VDR intron 8 G>A, rs1544410 | ||
| AA and AG | 71 | 61 |
| GG | 51 | 48 |
| Missing | 155 | 143 |
“Best” refers to children who are day-8 blood and day-29 bone marrow MRD negative (<0.01%); “worst” refers to children who are bone marrow day-29 MRD positive (> 0.01%).