Table 4 Recovery and survival of... | American Society of Hematology

Table 4

Recovery and survival of transfused murine platelets

	No. of mice	Recovery, %	Survival, d
Modified murine platelets transfused into WT mice
Fresh (unmodified)	6	89 ± 24	3.4 ± 0.3
UDP-glucose, 4-hour buffer stored at 0°C	6	43 ± 19*	2.5 ± 0.1*
UDP-galactose, 4-hour buffer stored at 0°C	6	79 ± 12	3.5 ± 0.2
UDP-glucose, 48-hour plasma stored at 4°C	6	44 ± 12*	2.5 ± 0.2*
UDP-galactose, 48-hour plasma stored at 4°C	6	33 ± 19*	2.5 ± 0.1*
Unmodified murine platelets transfused into WT mice
Fresh	3	97 ± 22	3.5 ± 0.3
4-hour plasma stored at 4°C	4	78 ± 19	3.5 ± 0.3
6-hour plasma stored at 4°C	3	88 ± 9	3.5 ± 0.4
24-hour plasma stored at 4°C	6	54 ± 28*	2.6 ± 0.4*
48-hour plasma stored at 4°C	6	42 ± 16*	2.0 ± 0.3*
6-hour plasma stored at 22°C**	3	2 ± 1*	ND†
Unmodified platelets transfused into WT or α_Mβ₂ integrin receptor knockout mice (KO)
Fresh into WT	3	79 ± 27	3.4 ± 0.1
Fresh into KO	3	76 ± 17	4.7 ± 0.4
48-hour 4°C stored into WT	3	36 ± 9*	2.5 ± 0.1*
48-hour 4°C stored into KO	3	45 ± 9*	2.4 ± 0.3*

	No. of mice	Recovery, %	Survival, d
Modified murine platelets transfused into WT mice
Fresh (unmodified)	6	89 ± 24	3.4 ± 0.3
UDP-glucose, 4-hour buffer stored at 0°C	6	43 ± 19*	2.5 ± 0.1*
UDP-galactose, 4-hour buffer stored at 0°C	6	79 ± 12	3.5 ± 0.2
UDP-glucose, 48-hour plasma stored at 4°C	6	44 ± 12*	2.5 ± 0.2*
UDP-galactose, 48-hour plasma stored at 4°C	6	33 ± 19*	2.5 ± 0.1*
Unmodified murine platelets transfused into WT mice
Fresh	3	97 ± 22	3.5 ± 0.3
4-hour plasma stored at 4°C	4	78 ± 19	3.5 ± 0.3
6-hour plasma stored at 4°C	3	88 ± 9	3.5 ± 0.4
24-hour plasma stored at 4°C	6	54 ± 28*	2.6 ± 0.4*
48-hour plasma stored at 4°C	6	42 ± 16*	2.0 ± 0.3*
6-hour plasma stored at 22°C**	3	2 ± 1*	ND†
Unmodified platelets transfused into WT or α_Mβ₂ integrin receptor knockout mice (KO)
Fresh into WT	3	79 ± 27	3.4 ± 0.1
Fresh into KO	3	76 ± 17	4.7 ± 0.4
48-hour 4°C stored into WT	3	36 ± 9*	2.5 ± 0.1*
48-hour 4°C stored into KO	3	45 ± 9*	2.4 ± 0.3*

Data are reported as averages plus or minus one standard deviation (SD).

— indicates not applicable; and ND, not determined.

P < .01 compared with fresh platelets.

For these studies, platelet recoveries were too low to determine platelet survivals.