In vivo APC beneficial effects
| Model, host . | Trigger . | Read out . | APC effect . | Sources . |
|---|---|---|---|---|
| Sepsis | ||||
| Human | Sepsis (high risk of death) | Death | Inhibits | Bernard et al,24 Bernard et al77 |
| Human | Sepsis (low risk of death) | Death | No effect | Abraham et al78 |
| Human | LPS | Thrombosis/inflammation | No effect | Kalil et al79 |
| Baboon* | E coli | Death | Inhibits | Taylor et al80 |
| Hamster | LPS | Inflammation | Inhibits | Hoffmann et al81 |
| Rat | LPS | Inflammation | Inhibits | Iba et al82 |
| Rat | LPS | Arterial blood pressure | Increases | Isobe et al83 |
| Rat | LPS | Cardiovascular dysfunction/inflammation | Inhibits | Favory et al84 |
| Pulmonary inflammation and injury | ||||
| Human | LPS | Thrombosis | Inhibits | Van der Poll et al85 |
| Human | LPS | Inflammation | Inhibits | Nick et al45 |
| Rat | LPS | Inflammation | Inhibits | Murakami et al44 |
| Rat | Acid aspiration | Inflammation | Inhibits | Jian et al86 |
| Rat | Smoke | Inflammation | Inhibits | Wong et al87 |
| Mouse* | Bleomycin | Fibrosis/inflammation | Inhibits | Shimizu et al,40 Yasui et al88 |
| Mouse* | Ovalbumin | Inflammation | Inhibits | Yuda et al41 |
| Stroke | ||||
| Rabbit | I/R | Neurologic injury | Inhibits | Yamauchi et al89 |
| Rat | I/R | Neurologic injury/thrombosis/inflammation | Inhibits | Zlokovic et al90 |
| Mouse*† | I/R | Neurologic injury/thrombosis/inflammation | Inhibits | Cheng et al,16 Cheng et al,70 Zlokovic et al,90 Fernández et al,91 Shibata et al92 |
| Mouse†‡ | NMDA | Apoptosis/neurologic injury | Inhibits | Guo et al,31 Liu et al60 |
| Wound healing/angiogenesis | ||||
| Rat | Biopsy | Wound closure | Promotes | Xue et al,93 Jackson et al94 |
| Mouse | None | Capillary formation | Promotes | Uchiba et al95 |
| Chick | None | Capillary formation | Promotes | Xue et al93 |
| Miscellaneous | ||||
| Intestinal | ||||
| Rat | I/R | Inflammation | Inhibits | Schoots et al96 |
| Acute pancreatitis | ||||
| Rat | Taurocholate | Inflammation | Inhibits | Yamenel et al97 |
| Gastric injury | ||||
| Rat | Stress | Thrombosis/inflammation | Inhibits | Isobe et al98 |
| Spinal cord injury | ||||
| Rat | Compression | Motor disturbance/inflammation | Inhibits | Taoka et al56 |
| Islet transplantation | ||||
| Mouse | Transplantation | Apoptosis/inflammation | Inhibits | Contreras et al99 |
| Model, host . | Trigger . | Read out . | APC effect . | Sources . |
|---|---|---|---|---|
| Sepsis | ||||
| Human | Sepsis (high risk of death) | Death | Inhibits | Bernard et al,24 Bernard et al77 |
| Human | Sepsis (low risk of death) | Death | No effect | Abraham et al78 |
| Human | LPS | Thrombosis/inflammation | No effect | Kalil et al79 |
| Baboon* | E coli | Death | Inhibits | Taylor et al80 |
| Hamster | LPS | Inflammation | Inhibits | Hoffmann et al81 |
| Rat | LPS | Inflammation | Inhibits | Iba et al82 |
| Rat | LPS | Arterial blood pressure | Increases | Isobe et al83 |
| Rat | LPS | Cardiovascular dysfunction/inflammation | Inhibits | Favory et al84 |
| Pulmonary inflammation and injury | ||||
| Human | LPS | Thrombosis | Inhibits | Van der Poll et al85 |
| Human | LPS | Inflammation | Inhibits | Nick et al45 |
| Rat | LPS | Inflammation | Inhibits | Murakami et al44 |
| Rat | Acid aspiration | Inflammation | Inhibits | Jian et al86 |
| Rat | Smoke | Inflammation | Inhibits | Wong et al87 |
| Mouse* | Bleomycin | Fibrosis/inflammation | Inhibits | Shimizu et al,40 Yasui et al88 |
| Mouse* | Ovalbumin | Inflammation | Inhibits | Yuda et al41 |
| Stroke | ||||
| Rabbit | I/R | Neurologic injury | Inhibits | Yamauchi et al89 |
| Rat | I/R | Neurologic injury/thrombosis/inflammation | Inhibits | Zlokovic et al90 |
| Mouse*† | I/R | Neurologic injury/thrombosis/inflammation | Inhibits | Cheng et al,16 Cheng et al,70 Zlokovic et al,90 Fernández et al,91 Shibata et al92 |
| Mouse†‡ | NMDA | Apoptosis/neurologic injury | Inhibits | Guo et al,31 Liu et al60 |
| Wound healing/angiogenesis | ||||
| Rat | Biopsy | Wound closure | Promotes | Xue et al,93 Jackson et al94 |
| Mouse | None | Capillary formation | Promotes | Uchiba et al95 |
| Chick | None | Capillary formation | Promotes | Xue et al93 |
| Miscellaneous | ||||
| Intestinal | ||||
| Rat | I/R | Inflammation | Inhibits | Schoots et al96 |
| Acute pancreatitis | ||||
| Rat | Taurocholate | Inflammation | Inhibits | Yamenel et al97 |
| Gastric injury | ||||
| Rat | Stress | Thrombosis/inflammation | Inhibits | Isobe et al98 |
| Spinal cord injury | ||||
| Rat | Compression | Motor disturbance/inflammation | Inhibits | Taoka et al56 |
| Islet transplantation | ||||
| Mouse | Transplantation | Apoptosis/inflammation | Inhibits | Contreras et al99 |