Clinical characteristics of 609 adults with recurring ALL
| Characteristic . | No. patients . |
|---|---|
| Age at first diagnosis | |
| 15-19 y | 117 |
| 20-34 y | 236 |
| 35-49 y | 49 |
| Older than 50 y | 74 |
| Sex | |
| Male | 382 |
| Female | 227 |
| WBC count at first diagnosis | |
| Less than 10 × 109/L | 248 |
| 10–49 × 109/L | 178 |
| More than 50 × 109/L | 181 |
| Unknown | 2 |
| Immunophenotype (44 unknown) | |
| B precursor | 409 |
| T-cell | 92 |
| Mature B | 12 |
| Null | 30 |
| Mixed | 22 |
| Unknown | 44 |
| Ph status (56 unknown) | |
| Positive | 120 |
| Negative | 433 |
| Risk group at first diagnosis (67 unknown) | |
| Standard | 287 |
| High | 135 |
| Very high | 120 |
| Unknown | 67 |
| Initial treatment at first diagnosis* | |
| CR1 | |
| Chemotherapy | 440 |
| Sibling allograft | 60 |
| MUD | 17 |
| Autograft | 80 |
| Other | 5† |
| Preremission‡ | |
| Sibling allograft | 6 |
| Autograft | 1 |
| Time from diagnosis to relapse | |
| Less than 1 y | 333 |
| 1-2 y | 160 |
| More than 2 y | 116 |
| Site of relapse, no. patients (8 unknown) | |
| BM alone | 523 |
| BM + CNS | 33 |
| CNS alone | 22 |
| Extramedullary | 23 |
| Unknown | 8 |
| Characteristic . | No. patients . |
|---|---|
| Age at first diagnosis | |
| 15-19 y | 117 |
| 20-34 y | 236 |
| 35-49 y | 49 |
| Older than 50 y | 74 |
| Sex | |
| Male | 382 |
| Female | 227 |
| WBC count at first diagnosis | |
| Less than 10 × 109/L | 248 |
| 10–49 × 109/L | 178 |
| More than 50 × 109/L | 181 |
| Unknown | 2 |
| Immunophenotype (44 unknown) | |
| B precursor | 409 |
| T-cell | 92 |
| Mature B | 12 |
| Null | 30 |
| Mixed | 22 |
| Unknown | 44 |
| Ph status (56 unknown) | |
| Positive | 120 |
| Negative | 433 |
| Risk group at first diagnosis (67 unknown) | |
| Standard | 287 |
| High | 135 |
| Very high | 120 |
| Unknown | 67 |
| Initial treatment at first diagnosis* | |
| CR1 | |
| Chemotherapy | 440 |
| Sibling allograft | 60 |
| MUD | 17 |
| Autograft | 80 |
| Other | 5† |
| Preremission‡ | |
| Sibling allograft | 6 |
| Autograft | 1 |
| Time from diagnosis to relapse | |
| Less than 1 y | 333 |
| 1-2 y | 160 |
| More than 2 y | 116 |
| Site of relapse, no. patients (8 unknown) | |
| BM alone | 523 |
| BM + CNS | 33 |
| CNS alone | 22 |
| Extramedullary | 23 |
| Unknown | 8 |
One BMT on unknown date.
Other indicates one reduced-intensity sibling allogeneic HSCT, one reduced-intensity MUD allogeneic HSCT, one reduced-intensity haploidentical HSCT, one fully conditioned haploidentical HSCT, and one unknown type.
Preremission indicates HSCT performed in absence of achieving CR1.