Consecutive patients and controls analyzed using 4-color FCM
Diagnosis . | No. in each cohort . |
|---|---|
| First cohort | |
| LGw/oRS patients (no. male/no. female) | 12 (7/5) |
| Controls (no. male/no. female) | 50 (24/26) |
| ITP | 14 |
| NHL without BM invasion | 10 |
| Anemia of chronic disease* | 7 |
| Healthy, marginal cytopenia† | 6 |
| HD without BM invasion | 3 |
| Iron-deficiency anemia | 2 |
| Alcoholic cytopenia or macrocytosis | 2 |
| Drug-induced anemia | 1 |
| Chronic obstructive lung disease | 1 |
| Renal failure | 1 |
| Infectious mononucleosis | 1 |
| Thalassemia | 1 |
| Pure white cell aplasia | 1 |
| Second cohort | |
| LGw/oRS patients (no. male/no. female) | 15 (10/5) |
| Controls (no. male/no. female) | 40 (21/19) |
| ITP | 9 |
| Healthy†‡ | 8 |
| NHL without BM invasion | 7 |
| Drug-induced cytopenia | 4 |
| Anemia of chronic disease* | 3 |
| Vitamin B12 deficiency | 2 |
| Renal failure | 2 |
| Alcoholic cytopenia | 1 |
| Chronic obstructive lung disease | 1 |
| Pure red cell aplasia | 1 |
| ATP | 1 |
| Hypothermia-induced cytopenia | 1 |
Diagnosis . | No. in each cohort . |
|---|---|
| First cohort | |
| LGw/oRS patients (no. male/no. female) | 12 (7/5) |
| Controls (no. male/no. female) | 50 (24/26) |
| ITP | 14 |
| NHL without BM invasion | 10 |
| Anemia of chronic disease* | 7 |
| Healthy, marginal cytopenia† | 6 |
| HD without BM invasion | 3 |
| Iron-deficiency anemia | 2 |
| Alcoholic cytopenia or macrocytosis | 2 |
| Drug-induced anemia | 1 |
| Chronic obstructive lung disease | 1 |
| Renal failure | 1 |
| Infectious mononucleosis | 1 |
| Thalassemia | 1 |
| Pure white cell aplasia | 1 |
| Second cohort | |
| LGw/oRS patients (no. male/no. female) | 15 (10/5) |
| Controls (no. male/no. female) | 40 (21/19) |
| ITP | 9 |
| Healthy†‡ | 8 |
| NHL without BM invasion | 7 |
| Drug-induced cytopenia | 4 |
| Anemia of chronic disease* | 3 |
| Vitamin B12 deficiency | 2 |
| Renal failure | 2 |
| Alcoholic cytopenia | 1 |
| Chronic obstructive lung disease | 1 |
| Pure red cell aplasia | 1 |
| ATP | 1 |
| Hypothermia-induced cytopenia | 1 |
ITP indicates immune thrombocytopenic purpura; NHL, non-Hodgkin lymphoma; HD, Hodgkin disease; ATP, amegakaryocytic thrombocytopenic purpura.
Ages were 61.9 ± 17.1 and 60.6 ± 17.4 years for LGw/oRS patients and controls, respectively, in the first cohort and 74.9 ± 8.6 and 61.1 ± 15.1 years for LGw/oRS patients and controls, respectively, in the second cohort.
First cohort: 3 congestive heart failure, 2 carcinoma without BM invasion (1 lung cancer, 1 pancreatic cancer), 1 fever of unknown origin, 1 undefined inflammation. Second cohort: 1 sarcoidosis, 1 rheumatoid arthritis, 1 pyoderma gangrenosum.
Patients who had marginal cytopenia or neutrophilia and were judged to be healthy after examination.
Seven marginal cytopenias and 1 physiologic.