Table 1. Globin genotypes of transgenic... | American Society of Hematology

Table 1.

Globin genotypes of transgenic sickle mouse models

Mouse model	Mouse α-globin	Mouse β-globin	Human α-globin	Human β^S-globin	% β^S
Normal	Yes	Yes	No	No	0
NY-S	Yes	Deleted	Yes	β^S	72.7³⁵
Berk-S^Antilles	Yes	Deleted	Yes	β^S-Antilles	49.3³⁶
NY-S/S^Antilles	Yes	Deleted	Yes	β^S/β^S-Antilles	42.2/35.9³⁷
Berk-S	Knock-out	Knock-out	Yes	β^S	∼100³⁸

Mouse model	Mouse α-globin	Mouse β-globin	Human α-globin	Human β^S-globin	% β^S
Normal	Yes	Yes	No	No	0
NY-S	Yes	Deleted	Yes	β^S	72.7³⁵
Berk-S^Antilles	Yes	Deleted	Yes	β^S-Antilles	49.3³⁶
NY-S/S^Antilles	Yes	Deleted	Yes	β^S/β^S-Antilles	42.2/35.9³⁷
Berk-S	Knock-out	Knock-out	Yes	β^S	∼100³⁸