Table 1. Incidence of disease-related... | American Society of Hematology

Table 1.

Incidence of disease-related morbidity in hemochromatosis homozygotes in studies with and without ascertainment bias

Study	Subjects studied	Number of homozygotes	Liver biopsy evaluation	Incidence of morbidity, %
Edwards et al^*	Healthy blood donors	26	Yes	0
Jackson et al^*	Healthy blood donors	63	No	0
Bulaj et al^†	Clinically unselected homozygotes from 291 families	214	Yes	29^‡
Powell et al^†	Homozygous relatives of 40 homozygous probands	51	Yes	10^1-153
Olynyk et al^†	Population-based	16	Yes	25
Asberg et al^†	Population-based	269	Yes	10
Beutler et al^†	Health-screening clinic	152	No	<1

Study	Subjects studied	Number of homozygotes	Liver biopsy evaluation	Incidence of morbidity, %
Edwards et al^*	Healthy blood donors	26	Yes	0
Jackson et al^*	Healthy blood donors	63	No	0
Bulaj et al^†	Clinically unselected homozygotes from 291 families	214	Yes	29^‡
Powell et al^†	Homozygous relatives of 40 homozygous probands	51	Yes	10^1-153
Olynyk et al^†	Population-based	16	Yes	25
Asberg et al^†	Population-based	269	Yes	10
Beutler et al^†	Health-screening clinic	152	No	<1

Studies with ascertainment bias.

Studies without ascertainment bias.

Male homozygous relatives of healthy hemochromatosis probands.

Male homozygotes.