Table 4. Hepatic necroinflammatory... | American Society of Hematology

Table 4.

Hepatic necroinflammatory activity and serum alanine aminotransferase

	HCV⁻patients			HCV⁺patients			P for HCV⁻ versus HCV⁺
	Entry	Final	P	Entry	Final	P	Entry	Final
Mean Ishak activity grade, all pathologists^4-150	0.42 ± 0.70	0.55 ± 0.58	.60 (n = 11)	1.64 ± 1.43	2.06 ± 1.75	.06 (n = 45)	.0003	< .0001
Serum ALT (IU/L)^4-151	16.5 ± 6.4	24.5 ± 13.3	.09	52.0 ± 72.8	66.2 ± 61.3	.34	.003	.0003

	HCV⁻patients			HCV⁺patients			P for HCV⁻ versus HCV⁺
	Entry	Final	P	Entry	Final	P	Entry	Final
Mean Ishak activity grade, all pathologists^4-150	0.42 ± 0.70	0.55 ± 0.58	.60 (n = 11)	1.64 ± 1.43	2.06 ± 1.75	.06 (n = 45)	.0003	< .0001
Serum ALT (IU/L)^4-151	16.5 ± 6.4	24.5 ± 13.3	.09	52.0 ± 72.8	66.2 ± 61.3	.34	.003	.0003

P values were generated by 2-tailed ttests.

Data are derived from the mean grade for the 3 pathologists.

Single determination closest to time of biopsy. Normal, below 40 IU/L.