Signs and symptoms of PNH
| Subjective |
| Fatigue, lethargy, asthenia, loss of sense of well-being |
| Abdominal pain |
| Dyspnea |
| Chest pain |
| Odynophagia* |
| Male impotence |
| Headache |
| Objective |
| Hemoglobinuria† |
| Scleral icterus, jaundice |
| Thromboembolic events‡ |
| Laboratory abnormalities |
| Cytopenias (anemia, thrombocytopenia, leukopenia, pancytopenia) |
| Evidence of intravascular hemolysis (elevated LDH, elevated indirect bilirubin, low haptoglobin) |
| Flow cytometry demonstrates deficiency of GPI-AP on a portion of red cells, granulocyte, and monocytes |
| Iron deficiency |
| Hemosiderinuria |
| Subjective |
| Fatigue, lethargy, asthenia, loss of sense of well-being |
| Abdominal pain |
| Dyspnea |
| Chest pain |
| Odynophagia* |
| Male impotence |
| Headache |
| Objective |
| Hemoglobinuria† |
| Scleral icterus, jaundice |
| Thromboembolic events‡ |
| Laboratory abnormalities |
| Cytopenias (anemia, thrombocytopenia, leukopenia, pancytopenia) |
| Evidence of intravascular hemolysis (elevated LDH, elevated indirect bilirubin, low haptoglobin) |
| Flow cytometry demonstrates deficiency of GPI-AP on a portion of red cells, granulocyte, and monocytes |
| Iron deficiency |
| Hemosiderinuria |