Risk factors in NMM
| . | Host . | Genetics . | Other . |
|---|---|---|---|
| Risk factors | Advanced age | Hypodiploidy | High S phase |
| Higher PS | Deletion (17p) | Circulating PCs | |
| Increased comorbidities | t(4;14), t(14;16), and t(14;20) | Reduced polyclonal BMPCs | |
| Deletion (1p) | High serum FLC | ||
| Addition (1q) Deletion (13q) by metaphase cytogenetics HR GEP signatures | Other extramedullary disease Early relapse |
| . | Host . | Genetics . | Other . |
|---|---|---|---|
| Risk factors | Advanced age | Hypodiploidy | High S phase |
| Higher PS | Deletion (17p) | Circulating PCs | |
| Increased comorbidities | t(4;14), t(14;16), and t(14;20) | Reduced polyclonal BMPCs | |
| Deletion (1p) | High serum FLC | ||
| Addition (1q) Deletion (13q) by metaphase cytogenetics HR GEP signatures | Other extramedullary disease Early relapse |
BMPCs, bone marrow plasma cells; FLC, free light chain; GEP, gene expression signature; PCs, plasma cells; PS, performance status.