Clinical features of disorders of neutrophil function.
| Clinical Features . | Associated Neutrophil Disorders* . |
|---|---|
| *Disorders not discussed in detail in the text are listed with accession numbers for Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM) | |
| †Hereditary atypical mycobacteriosis represents a defect in monocyte and macrophage,16 rather than neutrophil, function. It is included because of the overlap in presentation with congenital disorders of neutrophil function, most of which also affect monocyte/macrophage function. | |
| Recurrent bacterial and/or fungal infections | All |
| Single opportunistic infection | All |
| Organisms associated with specific disorders: | |
| Aspergillus | CGD |
| Atypical mycobacteria | Atypical mycobacteriosis† (OMIM 209950) |
| Bacillus Calmette-Guerin (BCG) – disseminated | CGD, atypical mycobacteriosis† |
| Burkholderia cepacia | CGD |
| Candida – invasive | CGD |
| Candida – mucocutaneous | Hyper-IgE syndrome (OMIM 147060) |
| Serratia marcescens | CGD |
| Marked leukocytosis with neutrophilia (absolute neutrophil count 30,000–100,000/mm3) | Leukocyte adhesion disorder, type 1 (OMIM 116920); congenital disorder of glycosylation, type IIc (OMIM 266265) |
| Delayed separation of the umbilical cord (> 30 d) | Leukocyte adhesion disorder, type 1 |
| Partial oculocutaneous albinism | Chédiak-Higashi syndrome (OMIM 214500) |
| Impaired resorption of primary teeth; coarse facies | Hyper-IgE syndrome |
| Clinical Features . | Associated Neutrophil Disorders* . |
|---|---|
| *Disorders not discussed in detail in the text are listed with accession numbers for Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM) | |
| †Hereditary atypical mycobacteriosis represents a defect in monocyte and macrophage,16 rather than neutrophil, function. It is included because of the overlap in presentation with congenital disorders of neutrophil function, most of which also affect monocyte/macrophage function. | |
| Recurrent bacterial and/or fungal infections | All |
| Single opportunistic infection | All |
| Organisms associated with specific disorders: | |
| Aspergillus | CGD |
| Atypical mycobacteria | Atypical mycobacteriosis† (OMIM 209950) |
| Bacillus Calmette-Guerin (BCG) – disseminated | CGD, atypical mycobacteriosis† |
| Burkholderia cepacia | CGD |
| Candida – invasive | CGD |
| Candida – mucocutaneous | Hyper-IgE syndrome (OMIM 147060) |
| Serratia marcescens | CGD |
| Marked leukocytosis with neutrophilia (absolute neutrophil count 30,000–100,000/mm3) | Leukocyte adhesion disorder, type 1 (OMIM 116920); congenital disorder of glycosylation, type IIc (OMIM 266265) |
| Delayed separation of the umbilical cord (> 30 d) | Leukocyte adhesion disorder, type 1 |
| Partial oculocutaneous albinism | Chédiak-Higashi syndrome (OMIM 214500) |
| Impaired resorption of primary teeth; coarse facies | Hyper-IgE syndrome |