Twenty-eight–day mortality in patients who received red cells at extremes of storage age
| . | Unadjusted analysis∗ . | Adjusted analysis† . | ||
|---|---|---|---|---|
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Units with storage age of ≤7 days in the fresh group vs older group‡ | ||||
| Only 1 RBC unit (n = 1909 in the fresh arm and n = 20 651 in older arm) | 1.18 (1.02-1.35) | .024 | 1.18 (1.02-1.36) | .026 |
| ≥2 RBC units (n = 2876 in the fresh arm and n = 20 651 in the older arm) | 1.17 (1.04-1.32) | .011 | 1.16 (1.03-1.31) | .015 |
| Units with storage age of ≤10 days in the fresh group vs older group§ | ||||
| Only 1 RBC unit (n = 2707 in the fresh arm and n = 20 651 in the older arm) | 1.09 (0.95-1.23) | .210 | 1.06 (0.93-1.21) | .350 |
| ≥2 RBC units (n = 5121 in the fresh arm and n = 20 651 in the older arm) | 1.15 (1.04-1.26) | .006 | 1.15 (1.04-1.27) | .006 |
| Units with storage age of >35 days in the older group vs fresh group|| | ||||
| Only 1 RBC unit (n = 3076 in the older arm and n = 12 308 in the fresh arm) | 1.02 (0.89-1.17) | .729 | 1.02 (0.88-1.17) | .753 |
| ≥2 RBC units (n = 2432 in the older arm and n = 12 308 in the fresh arm) | 1.07 (0.92-1.24) | .341 | 1.03 (0.88-1.19) | .737 |
| . | Unadjusted analysis∗ . | Adjusted analysis† . | ||
|---|---|---|---|---|
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Units with storage age of ≤7 days in the fresh group vs older group‡ | ||||
| Only 1 RBC unit (n = 1909 in the fresh arm and n = 20 651 in older arm) | 1.18 (1.02-1.35) | .024 | 1.18 (1.02-1.36) | .026 |
| ≥2 RBC units (n = 2876 in the fresh arm and n = 20 651 in the older arm) | 1.17 (1.04-1.32) | .011 | 1.16 (1.03-1.31) | .015 |
| Units with storage age of ≤10 days in the fresh group vs older group§ | ||||
| Only 1 RBC unit (n = 2707 in the fresh arm and n = 20 651 in the older arm) | 1.09 (0.95-1.23) | .210 | 1.06 (0.93-1.21) | .350 |
| ≥2 RBC units (n = 5121 in the fresh arm and n = 20 651 in the older arm) | 1.15 (1.04-1.26) | .006 | 1.15 (1.04-1.27) | .006 |
| Units with storage age of >35 days in the older group vs fresh group|| | ||||
| Only 1 RBC unit (n = 3076 in the older arm and n = 12 308 in the fresh arm) | 1.02 (0.89-1.17) | .729 | 1.02 (0.88-1.17) | .753 |
| ≥2 RBC units (n = 2432 in the older arm and n = 12 308 in the fresh arm) | 1.07 (0.92-1.24) | .341 | 1.03 (0.88-1.19) | .737 |
ICU, intensive care unit.
95% CIs and P values calculated with a logistic regression model with trial as a fixed effect.
Adjusted for age, sex, blood type, and local at randomization (ICU or not ICU).
Compares patients allocated to the fresh group who received red cells with storage age of ≤7 days with all patients allocated to the older group.
Compares patients allocated to fresh group who received red cells with storage age of ≤10 days with all patients allocated to the older group.
Compares patients allocated to the older group who received red cells with storage age of >35 days with all patients allocated to the fresh group.