Univariate and multivariable analysis for OS
| . | Univariate . | Multivariable . |
|---|---|---|
| Biological sex | ||
| M | 1.24 (0.66-2.33) | |
| F | Ref. | |
| Age | 1.08(1.04-1.12) | 1.09(1.03-1.16) |
| Rai stage at diagnosis | ||
| 0 | Ref. | |
| I-II | 1.23(0.59-2.55) | |
| III-IV | 4.56(1.66-12.51) | |
| Splenomegaly | ||
| Yes | 1.44 (0.64-3.25) | |
| No | Ref. | |
| Lymph nodes at diagnosis >5 cm | ||
| Yes | 0.88 (0.11-7.02) | |
| No | Ref. | |
| IgG <400 mg/dl | ||
| Yes | 5.67 (0.69-46.35) | |
| No | Ref. | |
| del(17p) | ||
| Yes | 0.51 (0.12-2.20) | |
| No | Ref. | |
| del(13q) | ||
| Yes | 0.57 (0.28-1.17) | |
| No | Ref. | |
| del(11q) | ||
| Yes | 2.50 (0.75-8.40) | |
| No | Ref. | |
| Trisomy 12 | ||
| Yes | 0.04 (0-36.83) | |
| No | Ref. | |
| IGHV gene | ||
| Unmutated | 3.86(1.76-8.44) | 3.81 (1.41-10.31) |
| Mutated | Ref. | Ref. |
| TP53 | ||
| Mutated | 2.83(1.20-6.68) | |
| WT | Ref. | |
| Familial CLL | ||
| Cases | 1.46(0.78-2.76) | |
| Controls | Ref. |
| . | Univariate . | Multivariable . |
|---|---|---|
| Biological sex | ||
| M | 1.24 (0.66-2.33) | |
| F | Ref. | |
| Age | 1.08(1.04-1.12) | 1.09(1.03-1.16) |
| Rai stage at diagnosis | ||
| 0 | Ref. | |
| I-II | 1.23(0.59-2.55) | |
| III-IV | 4.56(1.66-12.51) | |
| Splenomegaly | ||
| Yes | 1.44 (0.64-3.25) | |
| No | Ref. | |
| Lymph nodes at diagnosis >5 cm | ||
| Yes | 0.88 (0.11-7.02) | |
| No | Ref. | |
| IgG <400 mg/dl | ||
| Yes | 5.67 (0.69-46.35) | |
| No | Ref. | |
| del(17p) | ||
| Yes | 0.51 (0.12-2.20) | |
| No | Ref. | |
| del(13q) | ||
| Yes | 0.57 (0.28-1.17) | |
| No | Ref. | |
| del(11q) | ||
| Yes | 2.50 (0.75-8.40) | |
| No | Ref. | |
| Trisomy 12 | ||
| Yes | 0.04 (0-36.83) | |
| No | Ref. | |
| IGHV gene | ||
| Unmutated | 3.86(1.76-8.44) | 3.81 (1.41-10.31) |
| Mutated | Ref. | Ref. |
| TP53 | ||
| Mutated | 2.83(1.20-6.68) | |
| WT | Ref. | |
| Familial CLL | ||
| Cases | 1.46(0.78-2.76) | |
| Controls | Ref. |
Variables significantly associated with lower OS are set in bold.