Univariate and multivariable analysis for TTFT
| . | Univariate, HR (95% CI) . | Multivariable, HR (95% CI) . |
|---|---|---|
| Sex | ||
| M | 1.47 (1.13-1.91) | |
| F | Ref. | |
| Age, y | 0.99 (0.98-1.01) | |
| Rai stage at diagnosis | ||
| 0 | Ref. | Ref. |
| I-II | 3.36 (2.49-4.53) | 2.34 (1.55-3.52) |
| III-IV | 23.94 (14.15-40.53) | 28.58 (11.42-71.49) |
| Splenomegaly | ||
| Yes | 3.83 (2.84-5.15) | 1.64 (1.11-2.44) |
| No | Ref. | Ref. |
| Lymph nodes at diagnosis >5 cm | ||
| Yes | 8.70 (5.26-14.39) | 8.40 (4.08-17.29) |
| No | Ref. | Ref. |
| IgG <400 mg/dL | ||
| Yes | 2.23 (0.98-5.08) | |
| No | Ref. | |
| del(17p) | ||
| Yes | 3.00 (1.97-4.57) | |
| No | Ref. | |
| del(13q) | ||
| Yes | 1.15 (0.88-1.51) | |
| No | Ref. | |
| del(11q) | ||
| Yes | 3.17 (2.04-4.94) | 1.88 (1.05-3.37) |
| No | Ref. | Ref. |
| Trisomy 12 | ||
| Yes | 1.37 (0.88-2.12) | |
| No | Ref. | |
| IGHV gene | ||
| Unmutated | 3.36 (2.50-4.53) | 2.43 (1.68-3.50) |
| Mutated | Ref. | Ref. |
| TP53 | ||
| Mutated | 1.70 (1.15-2.51) | |
| WT | Ref. | |
| Familial CLL | ||
| Cases | 1.45 (1.12-1.89) | |
| Controls | Ref. |
| . | Univariate, HR (95% CI) . | Multivariable, HR (95% CI) . |
|---|---|---|
| Sex | ||
| M | 1.47 (1.13-1.91) | |
| F | Ref. | |
| Age, y | 0.99 (0.98-1.01) | |
| Rai stage at diagnosis | ||
| 0 | Ref. | Ref. |
| I-II | 3.36 (2.49-4.53) | 2.34 (1.55-3.52) |
| III-IV | 23.94 (14.15-40.53) | 28.58 (11.42-71.49) |
| Splenomegaly | ||
| Yes | 3.83 (2.84-5.15) | 1.64 (1.11-2.44) |
| No | Ref. | Ref. |
| Lymph nodes at diagnosis >5 cm | ||
| Yes | 8.70 (5.26-14.39) | 8.40 (4.08-17.29) |
| No | Ref. | Ref. |
| IgG <400 mg/dL | ||
| Yes | 2.23 (0.98-5.08) | |
| No | Ref. | |
| del(17p) | ||
| Yes | 3.00 (1.97-4.57) | |
| No | Ref. | |
| del(13q) | ||
| Yes | 1.15 (0.88-1.51) | |
| No | Ref. | |
| del(11q) | ||
| Yes | 3.17 (2.04-4.94) | 1.88 (1.05-3.37) |
| No | Ref. | Ref. |
| Trisomy 12 | ||
| Yes | 1.37 (0.88-2.12) | |
| No | Ref. | |
| IGHV gene | ||
| Unmutated | 3.36 (2.50-4.53) | 2.43 (1.68-3.50) |
| Mutated | Ref. | Ref. |
| TP53 | ||
| Mutated | 1.70 (1.15-2.51) | |
| WT | Ref. | |
| Familial CLL | ||
| Cases | 1.45 (1.12-1.89) | |
| Controls | Ref. |
Variables significantly associated with lower TTFT are set in bold.
Ref., reference; WT, wild type.