Definition of T-ICAHT grading
| . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|
| Early T-ICAHT (days 0-30), d | — | — | — | — |
| PLT count <50 × 109/L | 1-6 | ≥7 | — | — |
| PLT count <20 × 109/L | — | — | 1-13 | ≥14 |
| Late T-ICAHT (days 31-100),∗ d | — | — | — | — |
| PLT count <100 × 109/L | ≥1 | — | — | — |
| PLT count <50 × 109/L | ≥1 | |||
| PLT count <20 × 109/L | — | — | 1-13 | ≥14 |
| . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|
| Early T-ICAHT (days 0-30), d | — | — | — | — |
| PLT count <50 × 109/L | 1-6 | ≥7 | — | — |
| PLT count <20 × 109/L | — | — | 1-13 | ≥14 |
| Late T-ICAHT (days 31-100),∗ d | — | — | — | — |
| PLT count <100 × 109/L | ≥1 | — | — | — |
| PLT count <50 × 109/L | ≥1 | |||
| PLT count <20 × 109/L | — | — | 1-13 | ≥14 |
Thrombocytopenia criteria (T-ICAHT) follows the principal logic of the existing N-ICAHT grading (Rejeski et al9). For early T-ICAHT, the cumulative length beneath the respective threshold is calculated, censoring at the time of disease progression, subsequent line of therapy, or death. Days of nonstable count recovery (<3 days) are counted to the cumulative total of days, as outlined previously.17
PLT, platelet.
Two or more laboratory tests or nontransient thrombocytopenia. For this study, we limited the duration of late T-ICAHT to day +100, though extending follow-up beyond this point may be appropriate depending on the clinical question and the quality of available follow-up data. The timeframe of PLT recovery defined as the first of 3 consecutive days with a PLT count of ≥20 × 10 /L in the absence of a PLT transfusionfor 7 consecutive days.18,19