HIF-PHIs approved for marketing
| HIF-PHI . | Recommended starting dose . | Maximal dose . | Dosing frequency . | Countries with approval for marketing . |
|---|---|---|---|---|
| Daprodustat | ND-CKD: 2 - 4 mg (ESA-naive), 4 mg (switch from ESA) DD-CKD: [Japan] 4 mg, [United States] 1 - 4 mg (ESA-naive), 4-12 mg (switch from ESA) | 24 mg | QD | United States (DD-CKD only), Japan |
| Desidustat | ND-CKD: 100 mg (ESA-naive), 100,125 or 150 mg (switch from ESA) DD-CKD: 100 mg | 150 mg | TIW | India |
| Enarodustat | ND-CKD and DD-CKD-PD: 2 mg DD-CKD: 4 mg | 8 mg | QD | China, Japan, Korea |
| Molidustat | ND-CKD: 25 mg (ESA-naive), 25 - 50 mg (switch from ESA) DD-CKD: 75 mg | 200 mg | QD | Japan |
| Roxadustat | [European Union] 70 mg for BW <100 kg, 100 mg for BW ≥100 kg [Japan] 50 mg (ESA-naive), 70 - 100 mg (switch from ESA) | 3.0 mg/kg BW | TIW | China, Chile, Egypt, European Union, Iceland, Japan, Kuwait, Lichtenstein, Mexico, Norway, Russia, Saudi Arabia, South Africa, South, Korea, Turkey, United Arab Emirates, United Kingdom |
| Vadadustat | 300 mg | 600 mg | QD | For DD-CKD only: United States, Australia, European Union, Korea, Taiwan For both DD- and ND-CKD: Japan |
| HIF-PHI . | Recommended starting dose . | Maximal dose . | Dosing frequency . | Countries with approval for marketing . |
|---|---|---|---|---|
| Daprodustat | ND-CKD: 2 - 4 mg (ESA-naive), 4 mg (switch from ESA) DD-CKD: [Japan] 4 mg, [United States] 1 - 4 mg (ESA-naive), 4-12 mg (switch from ESA) | 24 mg | QD | United States (DD-CKD only), Japan |
| Desidustat | ND-CKD: 100 mg (ESA-naive), 100,125 or 150 mg (switch from ESA) DD-CKD: 100 mg | 150 mg | TIW | India |
| Enarodustat | ND-CKD and DD-CKD-PD: 2 mg DD-CKD: 4 mg | 8 mg | QD | China, Japan, Korea |
| Molidustat | ND-CKD: 25 mg (ESA-naive), 25 - 50 mg (switch from ESA) DD-CKD: 75 mg | 200 mg | QD | Japan |
| Roxadustat | [European Union] 70 mg for BW <100 kg, 100 mg for BW ≥100 kg [Japan] 50 mg (ESA-naive), 70 - 100 mg (switch from ESA) | 3.0 mg/kg BW | TIW | China, Chile, Egypt, European Union, Iceland, Japan, Kuwait, Lichtenstein, Mexico, Norway, Russia, Saudi Arabia, South Africa, South, Korea, Turkey, United Arab Emirates, United Kingdom |
| Vadadustat | 300 mg | 600 mg | QD | For DD-CKD only: United States, Australia, European Union, Korea, Taiwan For both DD- and ND-CKD: Japan |
ESA-naive is defined as no previous use of ESA.
BW, body weight; DD, dialysis-dependent (maintenance); ND, non–dialysis-dependent; QD, once daily; TIW, three times weekly.