Risk-assessment tools and clinical biomarkers associated with POD24
| . | Components . | Risk groups . | Survival . | POD24 . |
|---|---|---|---|---|
| FLIPI | Age; stage; Hb; LDH; nodal sites | Low: 0-1 Intermediate: 2-3 High: 4-5 | Low: 92% Intermediate: 90% High: 67% | Low/Intermediate: 4%-6% High: 7%-14% |
| FLIPI2 | B2M; diameter lymph node; BMI; age | Low: 0 Intermediate: 1-2 High: 3-5 | Low: 91% Intermediate: 69% High: 51% | |
| PRIMA-PI | B2M; BMI | Low: B2M ≤ 3, no BMI Intermediate: B2M ≤ 3 with BMI High: B2M > 3 | Low: 69% Intermediate: 55% High: 37% | Low: 5% Intermediate: 7% High: 12% |
| FLEX | Male sex; sum of lesion dimension; grade 3A; extranodal sites; ECOG; Hb; B2M; NK cell count; LDH | Low: 0-2 High: 3-9 | Low: 86% High: 68% | Low: 5% High: 8% |
| m7-FLIPI | FLIPI; ECOG; mutation status of 7 genes (ARID1A, CARD11, CREBBP, EP300, EZH2, FOXO1, MEF2B) | Low: <0.8 High: >0.8 | Low: 77% High: 38% | Low: 7% High: 17% |
| POD24-PI | High-risk FLIPI; mutation status of 3 genes (EP300, EZH2, FOXO1) | Low: <0.71 High: >0.71 | Low: 77% High: 50% | Low: 4% High: 14% |
| . | Components . | Risk groups . | Survival . | POD24 . |
|---|---|---|---|---|
| FLIPI | Age; stage; Hb; LDH; nodal sites | Low: 0-1 Intermediate: 2-3 High: 4-5 | Low: 92% Intermediate: 90% High: 67% | Low/Intermediate: 4%-6% High: 7%-14% |
| FLIPI2 | B2M; diameter lymph node; BMI; age | Low: 0 Intermediate: 1-2 High: 3-5 | Low: 91% Intermediate: 69% High: 51% | |
| PRIMA-PI | B2M; BMI | Low: B2M ≤ 3, no BMI Intermediate: B2M ≤ 3 with BMI High: B2M > 3 | Low: 69% Intermediate: 55% High: 37% | Low: 5% Intermediate: 7% High: 12% |
| FLEX | Male sex; sum of lesion dimension; grade 3A; extranodal sites; ECOG; Hb; B2M; NK cell count; LDH | Low: 0-2 High: 3-9 | Low: 86% High: 68% | Low: 5% High: 8% |
| m7-FLIPI | FLIPI; ECOG; mutation status of 7 genes (ARID1A, CARD11, CREBBP, EP300, EZH2, FOXO1, MEF2B) | Low: <0.8 High: >0.8 | Low: 77% High: 38% | Low: 7% High: 17% |
| POD24-PI | High-risk FLIPI; mutation status of 3 genes (EP300, EZH2, FOXO1) | Low: <0.71 High: >0.71 | Low: 77% High: 50% | Low: 4% High: 14% |
BMI, body mass index; Hb, hemoglobin.