Table 1. Differential diagnosis for CAPS... | American Society of Hematology

Table 1.

Differential diagnosis for CAPS

Nonobstetric differentials
• Heparin-induced thrombocytopenia ^* Variants • Primary TMA: ○ Thrombotic thrombocytopenia purpura ○ Complement-mediated TMA ○ Drug-induced TMA ○ Shiga-toxin–induced hemolytic uremic syndrome • DIC • Sepsis, including rare disorders such as hemorrhagic viral infections • Malignancy • Malignant hypertension (ie, scleroderma renal crisis) • Drug-related microangiopathic syndromes • Antineutrophil cytoplasmic autoantibody–associated vasculitis • Endocarditis • Purpura fulminans • Systemic rheumatic disease (ie, systemic lupus erythematous, scleroderma, antiphospholipid syndrome, etc)

Nonobstetric differentials

• Heparin-induced thrombocytopenia ^* Variants
• Primary TMA:
   ○ Thrombotic thrombocytopenia purpura
   ○ Complement-mediated TMA
   ○ Drug-induced TMA
   ○ Shiga-toxin–induced hemolytic uremic syndrome
• DIC
• Sepsis, including rare disorders such as hemorrhagic viral infections
• Malignancy
• Malignant hypertension (ie, scleroderma renal crisis)
• Drug-related microangiopathic syndromes
• Antineutrophil cytoplasmic autoantibody–associated vasculitis
• Endocarditis
• Purpura fulminans
• Systemic rheumatic disease (ie, systemic lupus erythematous, scleroderma, antiphospholipid syndrome, etc)

Obstetric differentials (which include all of the above)
• Preeclampsia and eclampsia • HELLP • Acute fatty liver of pregnancy

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