Summary of pregnancy outcomes in MPN patients within last 5 years
| Study . | No. of patients/ no. of pregnancies) . | MPN type (%) . | Treatments (%) . | Maternal/Fetal Complications (%) . | Live births (%) . |
|---|---|---|---|---|---|
| Elli et al. (2019)39 | 7/11 | PV (100) | ASA (91) IFN (18.2) LMWH (36) | Early pregnancy loss (9.1) Preterm (9.1) Stillbirth (18.2) | 81.8 |
| Gangat et al. (2020)25 | 61/102 | ET (90.1) PV (6.6) MF (3.3) | ASA (60) LMWH (9) IFN (15) | Hemorrhage (7) Thrombosis (4) Preeclampsia (4) Early pregnancy loss (31) Stillbirth (1) Preterm (2) IUGR (3) | 67 |
| Gangat et al. (2021)16 | 16/24 | MF (100) | ASA (58.3) LMWH (30) pIFN (8.3) | Hemorrhage (12.5) Thrombosis (0) Early pregnancy loss (20.8) Stillbirth (8.3) Preterm (8.3) IUGR (4.2) | 70.8 |
| How et al. (2020)23 | 52/121 | ET (100) | ASA (61.2) IFN (1.6) LMWH (31.7) | Hemorrhage (5.8) Thrombosis (2.5) Preeclampsia (3.3) Gestational HTN (0.8) Early pregnancy loss (32.2) Stillbirth (0.8) Preterm (7.4) IUGR (2.5) | 69 |
| İskender et al. (2021)30 | 21/21 | ET (100) | ASA (85.7) LMWH (66.7) pIFN (9.5) | Thrombosis (9.5) Preeclampsia (7.1) Early pregnancy loss (33.3) Stillbirth (0) Preterm (21.4) IUGR (14.3) | 66.7 |
| Landtblom et al. (2022)18 | 229/342 | ET (70) PV (11.8) MF (10.5) MPNU (8.7) | NA | Hemorrhage (14) Thrombosis (1) Preeclampsia, HELLP, gestational HTN (6) Preterm (12) Stillbirth (0.6) | NA |
| Lapoirie et al. (2020)40 | 14/27 | ET (64.3) PV (35.7) | ASA (67) LMWH (66.7) IFN (22) | Hemorrhage (11) Thrombosis (15) Early pregnancy loss (22.2) Stillbirth (4) Preterm (15) IUGR (15) | 70 |
| Maze et al. (2023)41 | 24/29 | ET (48) PV (31) MF (14) MPN NOS (7) | ASA (83) LMWH (17) IFN (17) Anagrelide (10) | Hemorrhage (3) Thrombosis (3) Preeclampsia (0) Early pregnancy loss (13.8) Stillbirth (4.2) | 83 |
| Schrickel et al. (2021)31 | 23/34 | ET (100) | ASA (58.8) LMWH (61.8) pIFN (58.8) IFN (41.2) | Hemorrhage (7.7) Thrombosis (0) Preeclampsia (4.2) Early pregnancy loss (26.5) | 73.5 |
| Wille et al. (2021)32 | 20/41 | PV (100) | ASA (56.1) LMWH (51.2) pIFN (7.3) IFN (7.3) | Hemorrhage (2.4) Thrombosis (2.4) Preeclampsia (2.4) Early pregnancy loss (44) Stillbirth (4.9) Preterm (7.3) | 51.2 |
| Wille et al. (2023)15 | 69/129 | PV (100) | ASA (48) LMWH (40) IFN (10.9) | Hemorrhage (15.5) Thrombosis (3.1) Preeclampsia (3.9) Early pregnancy loss (24.8) Stillbirth (7) Preterm (17.8) | 68.2 |
| Study . | No. of patients/ no. of pregnancies) . | MPN type (%) . | Treatments (%) . | Maternal/Fetal Complications (%) . | Live births (%) . |
|---|---|---|---|---|---|
| Elli et al. (2019)39 | 7/11 | PV (100) | ASA (91) IFN (18.2) LMWH (36) | Early pregnancy loss (9.1) Preterm (9.1) Stillbirth (18.2) | 81.8 |
| Gangat et al. (2020)25 | 61/102 | ET (90.1) PV (6.6) MF (3.3) | ASA (60) LMWH (9) IFN (15) | Hemorrhage (7) Thrombosis (4) Preeclampsia (4) Early pregnancy loss (31) Stillbirth (1) Preterm (2) IUGR (3) | 67 |
| Gangat et al. (2021)16 | 16/24 | MF (100) | ASA (58.3) LMWH (30) pIFN (8.3) | Hemorrhage (12.5) Thrombosis (0) Early pregnancy loss (20.8) Stillbirth (8.3) Preterm (8.3) IUGR (4.2) | 70.8 |
| How et al. (2020)23 | 52/121 | ET (100) | ASA (61.2) IFN (1.6) LMWH (31.7) | Hemorrhage (5.8) Thrombosis (2.5) Preeclampsia (3.3) Gestational HTN (0.8) Early pregnancy loss (32.2) Stillbirth (0.8) Preterm (7.4) IUGR (2.5) | 69 |
| İskender et al. (2021)30 | 21/21 | ET (100) | ASA (85.7) LMWH (66.7) pIFN (9.5) | Thrombosis (9.5) Preeclampsia (7.1) Early pregnancy loss (33.3) Stillbirth (0) Preterm (21.4) IUGR (14.3) | 66.7 |
| Landtblom et al. (2022)18 | 229/342 | ET (70) PV (11.8) MF (10.5) MPNU (8.7) | NA | Hemorrhage (14) Thrombosis (1) Preeclampsia, HELLP, gestational HTN (6) Preterm (12) Stillbirth (0.6) | NA |
| Lapoirie et al. (2020)40 | 14/27 | ET (64.3) PV (35.7) | ASA (67) LMWH (66.7) IFN (22) | Hemorrhage (11) Thrombosis (15) Early pregnancy loss (22.2) Stillbirth (4) Preterm (15) IUGR (15) | 70 |
| Maze et al. (2023)41 | 24/29 | ET (48) PV (31) MF (14) MPN NOS (7) | ASA (83) LMWH (17) IFN (17) Anagrelide (10) | Hemorrhage (3) Thrombosis (3) Preeclampsia (0) Early pregnancy loss (13.8) Stillbirth (4.2) | 83 |
| Schrickel et al. (2021)31 | 23/34 | ET (100) | ASA (58.8) LMWH (61.8) pIFN (58.8) IFN (41.2) | Hemorrhage (7.7) Thrombosis (0) Preeclampsia (4.2) Early pregnancy loss (26.5) | 73.5 |
| Wille et al. (2021)32 | 20/41 | PV (100) | ASA (56.1) LMWH (51.2) pIFN (7.3) IFN (7.3) | Hemorrhage (2.4) Thrombosis (2.4) Preeclampsia (2.4) Early pregnancy loss (44) Stillbirth (4.9) Preterm (7.3) | 51.2 |
| Wille et al. (2023)15 | 69/129 | PV (100) | ASA (48) LMWH (40) IFN (10.9) | Hemorrhage (15.5) Thrombosis (3.1) Preeclampsia (3.9) Early pregnancy loss (24.8) Stillbirth (7) Preterm (17.8) | 68.2 |
The meta-analysis by Maze et al. provides a comprehensive synthesis of 22 studies from 1996-2018.13
Meta-analysis of 22 studies.
ASA, aspirin; HELLP, hemolysis, elevated liver enzymes, and low platelets; HTN, hypertension; IFN, interferon; IUGR, intrauterine growth restriction; MPNU, myeloproliferative neoplasm unclassified; NOS, not otherwise specified; pIFN, pegylated interferon.